Evidence map›Paper›PMID 42450352›Full record

ArticleInternational journal of molecular sciences2026

Integrated Analysis of mRNA and microRNA Expression in Corneal Impression Cytology Samples from Patients with

Shuailin Li, Tanja Stachon, Fabian Norbert Fries, Mária Csidey, Annamária Náray, Anita Csorba, Ágnes Élő, Berthold Seitz, Zoltán Zsolt Nagy, Erika Maka and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Shuailin LiDr. Rolf M. Schwiete Center for Limbal Stem Cell and Congenital Aniridia Research, Saarland University, 66424 Homburg, Germany.ORCID 0009-0007-2251-6242
Tanja StachonDr. Rolf M. Schwiete Center for Limbal Stem Cell and Congenital Aniridia Research, Saarland University, 66424 Homburg, Germany.
Fabian Norbert FriesDr. Rolf M. Schwiete Center for Limbal Stem Cell and Congenital Aniridia Research, Saarland University, 66424 Homburg, Germany.ORCID 0000-0002-8526-4712
Mária CsideyDepartment of Ophthalmology, Semmelweis University, 1085 Budapest, Hungary.ORCID 0000-0003-1542-6592
Annamária NárayDr. Rolf M. Schwiete Center for Limbal Stem Cell and Congenital Aniridia Research, Saarland University, 66424 Homburg, Germany.
Anita CsorbaDepartment of Ophthalmology, Semmelweis University, 1085 Budapest, Hungary.
Ágnes ÉlőDepartment of Ophthalmology, Semmelweis University, 1085 Budapest, Hungary.
Berthold SeitzDepartment of Ophthalmology, Saarland University Medical Center, 66424 Homburg, Germany.ORCID 0000-0001-9701-8204
Zoltán Zsolt NagyDepartment of Ophthalmology, Semmelweis University, 1085 Budapest, Hungary.
Erika MakaDepartment of Ophthalmology, Semmelweis University, 1085 Budapest, Hungary.ORCID 0000-0002-3631-3506
Marta CortonDepartment of Genetics and Genomics, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz University Hospital, Universidad Autónoma de Madrid (IIS-FJD, UAM), 28040 Madrid, Spain.
Eszter JávorszkyMTA-SE Lendület Nephrogenetic Laboratory, Hungarian Academy of Sciences, 1051 Budapest, Hungary.ORCID 0000-0002-7834-8854
Kálmán ToryMTA-SE Lendület Nephrogenetic Laboratory, Hungarian Academy of Sciences, 1051 Budapest, Hungary.ORCID 0000-0002-0316-6212
Nicole LudwigDepartment of Human Genetics, Saarland University, 66424 Homburg, Germany.ORCID 0000-0003-4703-7567
Nóra SzentmáryDr. Rolf M. Schwiete Center for Limbal Stem Cell and Congenital Aniridia Research, Saarland University, 66424 Homburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to measure mRNA and miRNA expression profile in corneal impression cytology (IC) samples from patients with congenital aniridia (CA) and healthy controls, and to elucidate the key genes and signaling pathways involved in aniridia-associated keratopathy (AAK). Corneal IC samples were collected from 14 patients with CA and 14 healthy controls. RNA sequencing was performed to identify differentially expressed genes (DEGs) and miRNAs. Correlations with age and AAK grade were analyzed, selected miRNAs were validated by RT-qPCR, and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were conducted to characterize biological functions and pathways. A total of 695 DEGs and 19 differentially expressed miRNAs were identified.

Indexed as

AniridiaCorneaMicroRNAsPAX6 Transcription FactorRNA, MessengerAdolescentAdultChildFemaleGene Expression ProfilingGene Expression RegulationHumansMaleSignal TransductionMicroRNAsPAX6 protein, humanPAX6 Transcription FactorRNA, Messengercongenital aniridiamicroRNAmRNAPAX6sequencing

Identifiers

PMID42450352
PMCPMC13361358

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.