Dietary PhIP Exposure Induces Intestinal Barrier Injury in Zebrafish Involving Proteobacteria-Associated Dysbiosis and Metabolic Remodeling.

Panpan Wang, Siwei Zhang, Ziwen Qü, Shuanglei Zhang, Di Wu, Yanbo Wang, Guoliang Li

Abstract read

In one paragraph

Article in Foods (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Panpan WangSchool of Food Science and Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.ORCID 0009-0008-1094-7974

Siwei ZhangSchool of Food Science and Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.

Ziwen QüSchool of Food Science and Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.

Shuanglei ZhangSchool of Food Science and Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.

Di WuInstitute for Global Food Security, School of Biological Sciences, Queen's University Belfast, 19 Chlorine Gardens, Belfast BT9 5DL, UK.

Yanbo WangSchool of Food and Health, Beijing Technology and Business University, Beijing 100048, China.ORCID 0000-0003-3428-4585

Guoliang LiSchool of Food Science and Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.

Funding

Cross-Innovation Open Project of Food Flavor and Health, Beijing Technology & Business University FFHCI-2026031Education Department of Shaanxi Province 25JC008National Natural Science Foundation of China 32302260Shaanxi Province Postdoctoral Science Foundation 2025BSHEDZZ031

6 · The paper itself

Abstract

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a major heat-induced contaminant in protein-rich foods, yet its effects on intestinal barrier homeostasis and luminal microecology remain insufficiently defined. In this study, adult zebrafish were exposed to dietary PhIP for 90 days at estimated intake doses of 0.006, 0.4, and 7.2 mg/kg bw/day to evaluate intestinal injury, microbial dysbiosis, and metabolic remodeling. PhIP exposure impaired growth-related indices and induced progressive intestinal lesions, accompanied by mucus barrier depletion, reduced goblet cell abundance, and downregulation of

Indexed as

gut microbiotaHeterocyclic aromatic aminesintestinal barrier injuryPhIPproteobacteriauntargeted metabolomicszebrafish

Identifiers

PMID42450381

DOI10.3390/foods15132262

PMCPMC13361864

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.