Evidence map›Paper›PMID 42450530›Full record

ArticleBiology2026

Integrated Proteomic and Metabolomic Analyses Characterise Molecular Alterations Associated with JSRV-Induced OPA.

Pei Zhang, Xujie Duan, Yu Wang, Anyu Bao, Xinqi Ma, Sixu Chen, Yufei Zhang, Shuying Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pei ZhangCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China.
Xujie DuanCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China.ORCID 0000-0002-1574-6038
Yu WangCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China.
Anyu BaoCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China.
Xinqi MaCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China.
Sixu ChenCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China.
Yufei ZhangCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China.ORCID 0000-0002-1163-1807
Shuying LiuCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China.

Funding

Inner Mongolia Education Depart-ment Innovation Team Project No.NMGIRT2412Inner Mongolia Grassland Talent Innovation Team Project No.20151031Inner Mongolia Major Special Program for Science and Technology Project No. 2021ZD0010National Natural Science Foundation of China No.32360863Science and Technology Program Projects of Inner Mongolia Autonomous Region 2025KYPT0126，2025KYPT0127University Innovation Team Construction Project of the Inner Mongolia Department of Education Project No.BR22-13-08
6 · The paper itself

Abstract

Ovine pulmonary adenocarcinoma (OPA), caused by the exogenous Jaagsiekte sheep retrovirus (JSRV), shares several pathological and molecular features with human lung adenocarcinoma, providing an important model for comparative oncology. JSRV pathogenesis is mostly studied at the transcriptome level, with systematic proteomic and metabolomic studies remaining insufficient. Therefore, this study aimed to systematically characterise the molecular alterations associated with JSRV-induced OPA by integrating direct data-independent acquisition proteomics and untargeted metabolomics. We established an OPA model by infecting lambs with JSRV and performed multi-omics analyses on the lesion and control lung tissues (

Indexed as

Jaagsiekte sheep retrovirusmetabolomicsovine pulmonary adenocarcinomaproteomics

Identifiers

PMID42450530
PMCPMC13359867

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.