Evidence mapPaperPMID 42450549Full record

ArticleBiology2026

Aerobic Exercise Preserves Skeletal Muscle Function in Middle-Aged Mice Through the miR-150-5p/miR-199a-5p-Wnt/FZD4 Signaling Pathway.

Le Zhang, Jingzi He, Li Wang, Huan Zhang

Abstract read
In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Le ZhangSchool of Physical Education, Yan'an University, Yan'an 716000, China.
Jingzi HeSchool of Physical Education, Yan'an University, Yan'an 716000, China.
Li WangSchool of Sports Medicine and Health, Chengdu Sport University, Chengdu 610041, China.
Huan ZhangWest China Medical Center, Sichuan University, Chengdu 610041, China.

Funding

Education Department of Shaanxi Province 24JK0715National Natural Science Foundation of China 82260285Science and Technology Department of Sichuan Province 2023NSFSC1181Yan'an University YDBK2022-115
6 · The paper itself

Abstract

MicroRNAs are important regulators of skeletal muscle development and regeneration; however, the molecular basis by which exercise-induced miRNAs preserve middle-aged muscle function remains to be elucidated. This study aimed to investigate how aerobic exercise delays skeletal muscle attenuation by reversing age-related miRNAs dysregulation in male mice. Twelve-month-old male C57BL/6J mice (MC) (

Indexed as

aerobic exercisemiddle-agedmiR-150-5pmiR-199a-5pmiRNA-seqsarcopenia

Identifiers

PMID42450549
PMCPMC13359755

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.