Evidence map›Paper›PMID 42450582›Full record

ArticleBiology2026

Mitochondrial-Targeted SS-31 Attenuates the Doxorubicin-Induced Cardiomyoblast H9C2 Cell Senescence.

Jiaojiao Fan, Jinzi Wu, Shuo Yan, Songlin Li, Peter S Rabinovitch, Xingyun Qi, Huiliang Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiaojiao FanDepartment of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA.
Jinzi WuDepartment of Medical Genetics & Molecular Biochemistry, Lewis Katz School of Medicine, Temple University, 3440 N Broad St., Kresge Hall, Philadelphia, PA 19140, USA.
Shuo YanDepartment of Medical Genetics & Molecular Biochemistry, Lewis Katz School of Medicine, Temple University, 3440 N Broad St., Kresge Hall, Philadelphia, PA 19140, USA.ORCID 0009-0002-9682-0910
Songlin LiDepartment of Medical Genetics & Molecular Biochemistry, Lewis Katz School of Medicine, Temple University, 3440 N Broad St., Kresge Hall, Philadelphia, PA 19140, USA.ORCID 0009-0001-3366-5805
Peter S RabinovitchDepartment of Laboratory Medicine and Pathology, University of Washington, 1959 NE Pacific St., Seattle, WA 98195, USA.
Xingyun QiJHSC Building, Department of Biology, Rutgers University, Camden, NJ 08103, USA.ORCID 0000-0003-1261-1362
Huiliang ZhangDepartment of Medical Genetics & Molecular Biochemistry, Lewis Katz School of Medicine, Temple University, 3440 N Broad St., Kresge Hall, Philadelphia, PA 19140, USA.ORCID 0000-0002-8967-1219

Funding

SPECIFICITY OF OXYGEN DNA DAMAGE AND MUTAGENESISP01AG001751 · NIA · UNIVERSITY OF WASHINGTON · PI RABINOVITCH, PETER S · 1985 to 2021
$29.6M
Deciphering the mitochondrial proton leakR35GM151226 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Huiliang Zhang · 2023 to 2026
$1.6M
Osmotic Regulation of a Peptide Ligand-Mediated SignalingR35GM151096 · NIGMS · RUTGERS THE STATE UNIV OF NJ CAMDEN · PI Xingyun Qi · 2023 to 2026
$1.6M
American Heart Association 19 CDA 34660311NIA NIH HHS P01 AG001751NIGMS NIH HHS R35 GM151096NIGMS NIH HHS R35GM151096NIGMS NIH HHS R35 GM151226NIGMS NIH HHS R35GM151226U.S. National Science Foundation NSF-DBI-2217757/25251567
6 · The paper itself

Abstract

Doxorubicin (DOX), an effective chemotherapeutic agent for many types of cancer, is known for significant cardiotoxic side effects, which largely limit its clinical usage. A 3 h treatment of cardiomyoblast H9C2 cells with a low concentration of DOX (100 nM) can induce senescence-associated β-galactosidase (SA β-gal) staining, a gold standard of cell senescence. In the current study, we comprehensively characterized the phenotype of the DOX-induced senescent cardiomyocytes for the first time. Establishing this

Indexed as

doxorubicinH9C2 cellmitochondriasenescenceSS-31

Identifiers

PMID42450582
PMCPMC13359912

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.