Evidence map›Paper›PMID 42450701›Full record

ArticleAnimals : an open access journal from MDPI2026

Inhaled Corticosteroids Influence Pulmonary Microbiota in Severe Equine Asthma.

Estelle Manguin, Robert P Dickson, Juliette Jamon, Valérie Dubuc, Mathilde Leclère

Abstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Estelle ManguinDepartment of Clinical Sciences, Université de Montréal, St-Hyacinthe, QC J2S 2M2, Canada.ORCID 0000-0001-9296-2714
Robert P DicksonDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-6875-4277
Juliette JamonDepartment of Clinical Sciences, Université de Montréal, St-Hyacinthe, QC J2S 2M2, Canada.
Valérie DubucDepartment of Clinical Sciences, Université de Montréal, St-Hyacinthe, QC J2S 2M2, Canada.ORCID 0000-0003-3386-0819
Mathilde LeclèreDepartment of Clinical Sciences, Université de Montréal, St-Hyacinthe, QC J2S 2M2, Canada.ORCID 0000-0002-3910-0370

Funding

Natural Sciences and Engineering Research Council of Canada 06090
6 · The paper itself

Abstract

The use of inhaled corticosteroids (ICs) could influence the respiratory microbiota. In animals with asthma it is, however, difficult to separate the immunomodulatory effects of ICs from their indirect effects via improvement of ventilation. Our objective was to determine if ICs alter the pulmonary microbiota independently from their effects on lung function, using a blinded, controlled trial in an experimental model of asthma exacerbation in horses. We treated horses with severe asthma with either bronchodilators alone, or in combination with ICs. Twelve horses in exacerbation received long-acting β2-agonist (LABA, salmeterol) or ICs/LABA (fluticasone/salmeterol) by inhalation, for 2 weeks. Lung function and bronchoalveolar lavages (BAL) were performed before and after treatment.

Indexed as

16S rRNA geneasthmacorticosteroidshorsesmicrobiome

Identifiers

PMID42450701
PMCPMC13359710

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.