Evidence map›Paper›PMID 42450719›Full record

ArticleAnimals : an open access journal from MDPI2026

Low-Coverage Whole-Genome Sequencing Identifies Loci Associated with Birth Weight in East Friesian × Hu Crossbred Sheep.

Yuheng Bai, Shaohua Jiao, Jianqi Yang, Jinwang Liu, Baohang Sun, Chunna Cao, Hanyang Gao, Rongbin Wang, Meiling Wang, Jiayao Qin and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yuheng BaiKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.ORCID 0009-0002-9388-1195
Shaohua JiaoKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Jianqi YangKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Jinwang LiuCollege of Veterinary Medicine, Northwest A&F University, Yangling 712100, China.
Baohang SunKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Chunna CaoKey Laboratory for Efficient Ruminant Breeding Technology of Higher Education Institutions in Shaanxi Province, College of Animal Engineering, Shaanxi A&F Technology University, Yangling 712100, China.
Hanyang GaoYulin Industrial Development Institute for Sheep & Goat, Yulin 719053, China.
Rongbin WangYulin Industrial Development Institute for Sheep & Goat, Yulin 719053, China.
Meiling WangYulin Industrial Development Institute for Sheep & Goat, Yulin 719053, China.
Jiayao QinCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Yuhe LiCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Hongying WangYuyang District Animal Husbandry Technology Extension Station, Yulin 719053, China.
Yu JiangKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Ran LiKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.

Funding

Natural Science Foundation of Shaanxi Province 2025JC-YBQN-319Shaanxi Province Generic Technology Research and Development Platform 2023GXJS-02-01Shaanxi Provincial Key Research and Development Program 2024NC2-GJHX-15
6 · The paper itself

Abstract

Birth weight is a key early-life trait in sheep that influences neonatal survival and subsequent growth, but its genetic basis remains incompletely understood. Here, we used low-coverage whole-genome sequencing (lcWGS)-based genotyping and genome-wide association analysis (GWAS) to investigate birth weight in 671 East Friesian × Hu crossbred lambs, achieving high imputation accuracy (98.5% allelic concordance). A total of 148 SNPs reached the suggestive significance threshold, of which 20 reached genome-wide significance. Among these signals, the chromosome 7 locus contained 69 suggestive variants spanning an approximately 6 kb interval within the SPATA7 region, including 14 genome-wide significant SNPs. Notably, 13 of these suggestive variants overlapped annotated enhancer intervals, of which 3 reached genome-wide significance. Portions of the associated interval also coincided with pituitary ATAC-seq and liver H3K4me1 ChIP-seq signals. Chr7:98,178,889 A > G, the most strongly associated SNP in this region, showed birth-weight differences among genotypes. Lambs carrying the AG genotype had significantly higher adjusted least-squares mean birth weight than AA lambs (3.81 vs. 3.56 kg; Δ = 0.25 kg, +7.0%). These findings prioritize the

Indexed as

birth weightGWASlcWGSsheepSPATA7

Identifiers

PMID42450719
PMCPMC13359455

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.