Evidence map›Paper›PMID 42451124›Full record

ArticleNutrients2026

Neuroprotective Effects of Sorghum Polyphenol in Alzheimer's Disease: In Vitro and In Silico Analyses.

Rasheed A Abdulraheem, Ralph N Martins, Rajapandiyan Krishnamoorthy, Mohammad A Alshuniaber, Prashant Bharadwaj, Zhaoyu Li, Ranil Coorey, Vijay Jayasena, Stuart K Johnson, W M A D Binosha Fernando

Abstract read
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In one paragraph

Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rasheed A AbdulraheemSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, Perth, WA 6027, Australia.
Ralph N MartinsSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, Perth, WA 6027, Australia.
Rajapandiyan KrishnamoorthyDepartment of Food Science and Nutrition, College of Food and Agriculture Science, King Saud University, Riyadh 11451, Saudi Arabia.
Mohammad A AlshuniaberDepartment of Food Science and Nutrition, College of Food and Agriculture Science, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0001-6358-0653
Prashant BharadwajSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, Perth, WA 6027, Australia.
Zhaoyu LiQueensland Brain Institute, University of Queensland, St Lucia, QLD 4072, Australia.ORCID 0000-0002-5222-6832
Ranil CooreySchool of Molecular and Life Sciences, Curtin University, Perth, WA 6102, Australia.ORCID 0000-0002-5261-1300
Vijay JayasenaDepartment of Nutrition and Food Science, Western Sydney University, Penrith, NSW 2751, Australia.
Stuart K JohnsonSchool of Molecular and Life Sciences, Curtin University, Perth, WA 6102, Australia.
W M A D Binosha FernandoSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, Perth, WA 6027, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectiveAccumulation of amyloid-beta (Aβ) senile plaques in the human brain is a major hallmark of Alzheimer's disease (AD), which manifests as progressive decline in memory and cognitive functions and currently lacks effective disease-modifying therapies. Emerging evidence demonstrates that polyphenol-rich plant foods are potential complementary therapies for AD.

methodsIn this study, we investigated crude polyphenol extracts (CPEs) and purified polyphenol extracts (PPEs) from three sorghum genotypes for their ability to inhibit Aβ

resultsCPEs and PPEs inhibited Aβ

conclusionsThis study demonstrates that polyphenol extracts from black and red sorghum genotypes exert strong multitarget neuroprotection against Aβ

Indexed as

Alzheimer DiseaseNeuroprotective AgentsPlant ExtractsPolyphenolsSorghumAmyloid beta-PeptidesAnimalsCell LineCell SurvivalComputer SimulationHumansMiceMitochondriaOxidative StressPeptide FragmentsSignal TransductionAmyloid beta-Peptidesamyloid beta-protein (1-42)Neuroprotective AgentsPeptide FragmentsPlant ExtractsPolyphenolsAlzheimer’s diseaseamyloid betapolyphenolssignalling pathwaysSorghum bicolor

Identifiers

PMID42451124
PMCPMC13364096

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.