ArticleNutrients2026
Toxicological Assessment of Oligofructans Derived from Raw Sugar Fermentation by
Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
BACKGROUND/
objectivesOligofructans are a category of non-digestible carbohydrates with beneficial effects on gut health and microbiota modulation. In this study, oligofructans were produced from raw sugar using
methodsThe acute toxicity assessment consisted of administering a single oral dose of 2000 mg/kg body weight (bw), whereas the subchronic toxicity assessment included oral dosages of 200, 600, and 2000 mg/kg/day for 90 days.
resultsIn the acute toxicity test, no mortality or toxicity was observed in the rats treated with a single dose of oligofructans during the 14-day observation period. The median lethal dose (LD
conclusionNo adverse effects were observed in either acute or subchronic toxicity studies at doses up to 2000 mg/kg/day. Moreover, oligofructans modulated the gut microbiota by promoting the growth of potentially beneficial commensal bacteria and reducing the taxa associated with inflammation or metabolic dysfunction. However, further studies are required to confirm these microbiome-related changes in humans.
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