Evidence map›Paper›PMID 42451601›Full record

ArticleMolecules (Basel, Switzerland)2026

Correlational Analysis of Liver Metabolites and Pharmacodynamic Indexes in Xanthoxylin-Treated Acute Liver Failure.

Fengfeng Xie, Huimin Luo, Yuchen Shen, Xiuqi Yu, Dudong Wei, Liba Xu, Hua Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fengfeng XieGuangxi Key Laboratory of Zhuang and Yao Ethnic Medicine/University Engineering Research Center of Development and Industrialization of Zhuang and Yao Ethnic Medicinal Materials, Guangxi/Guangxi Engineering Research Center of Ethnic Medicine Resources and Application, Guangxi University of Chinese Medicine, Nanning 530200, China.
Huimin LuoGuangxi Key Laboratory of Zhuang and Yao Ethnic Medicine/University Engineering Research Center of Development and Industrialization of Zhuang and Yao Ethnic Medicinal Materials, Guangxi/Guangxi Engineering Research Center of Ethnic Medicine Resources and Application, Guangxi University of Chinese Medicine, Nanning 530200, China.
Yuchen ShenGuangxi Key Laboratory of Zhuang and Yao Ethnic Medicine/University Engineering Research Center of Development and Industrialization of Zhuang and Yao Ethnic Medicinal Materials, Guangxi/Guangxi Engineering Research Center of Ethnic Medicine Resources and Application, Guangxi University of Chinese Medicine, Nanning 530200, China.
Xiuqi YuGuangxi Key Laboratory of Zhuang and Yao Ethnic Medicine/University Engineering Research Center of Development and Industrialization of Zhuang and Yao Ethnic Medicinal Materials, Guangxi/Guangxi Engineering Research Center of Ethnic Medicine Resources and Application, Guangxi University of Chinese Medicine, Nanning 530200, China.
Dudong WeiGuangxi Key Laboratory of Zhuang and Yao Ethnic Medicine/University Engineering Research Center of Development and Industrialization of Zhuang and Yao Ethnic Medicinal Materials, Guangxi/Guangxi Engineering Research Center of Ethnic Medicine Resources and Application, Guangxi University of Chinese Medicine, Nanning 530200, China.
Liba XuGuangxi Key Laboratory of Zhuang and Yao Ethnic Medicine/University Engineering Research Center of Development and Industrialization of Zhuang and Yao Ethnic Medicinal Materials, Guangxi/Guangxi Engineering Research Center of Ethnic Medicine Resources and Application, Guangxi University of Chinese Medicine, Nanning 530200, China.
Hua ZhuGuangxi Key Laboratory of Zhuang and Yao Ethnic Medicine/University Engineering Research Center of Development and Industrialization of Zhuang and Yao Ethnic Medicinal Materials, Guangxi/Guangxi Engineering Research Center of Ethnic Medicine Resources and Application, Guangxi University of Chinese Medicine, Nanning 530200, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute liver failure (ALF) is characterized by a rapid decline in liver function, leading to metabolic and organ failure. This study employed liver metabolomics, Nuclear Factor kappa-B (NF-κB) signaling pathway analysis, and inflammatory factor profiling to investigate the therapeutic mechanisms of xanthoxylin in ALF. Xanthoxylin administration led to increased antioxidant levels and reduced markers of inflammation and tissue damage. Xanthoxylin downregulated the messenger RNA (mRNA) expression of Nitric Oxide Synthase (

Indexed as

LiverLiver Failure, AcuteMetabolomeAnimalsAntioxidantsGene Expression RegulationMaleMetabolomicsNF-kappa BRatsSignal TransductionAntioxidantsNF-kappa Bacute liver failureinflammatory factorsmetabolitesNF-κB signaling pathwayxanthoxylin

Identifiers

PMID42451601
PMCPMC13363226

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.