ArticleJournal of biosciences2026
Expression of Nischarin increases with postnatal hippocampal maturation and regulates cofilin phosphorylation.
Article in Journal of biosciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hippocampus, critical for memory integration and synaptic plasticity, undergoes cytoskeletal reorganization during development and maturation, a process regulated by cofilin phosphorylation dynamics. Nischarin is a tumor-suppressive scaffold protein, yet its role in neurodevelopment remains unexplored. This study investigated the spatiotemporal expression of Nischarin and its effect on cofilin during postnatal hippocampal maturation in rats. Using western blot, quantitative reverse transcription-polymerase chain reaction, and shRNA-mediated knockdown in adult rat hippocampal neurons and Neuro-2a cells, we demonstrated that Nischarin expression progressively increased from postnatal day 7 to P28, inversely correlating with declining phosphorylated cofilin levels. Mechanistically, Nischarin reduced phosphorylated cofilin levels by suppressing PAK1/LIMK1 activity. Immunofluorescence revealed that Nischarin knockdown disrupted the subcellular distribution of phosphorylated cofilin by impeding its translocation from the cytoplasm to the nucleus. These findings indicate Nischarin regulates cofilin activity via dual mechanisms: inhibiting phosphorylation through the PAK1/LIMK1 pathway and modulating phosphorylated cofilin nuclear translocation. The study highlights the role of Nischarin in hippocampal neuronal maturation by orchestrating cytoskeletal remodeling and suggests its therapeutic potential in neurodegenerative diseases linked to cofilin dysregulation.
Indexed as
Identifiers
42452806What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.