ArticleUpsala journal of medical sciences2026
Altered placental expression of small humanin-like peptides in gestational diabetes mellitus.
Article in Upsala journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Background: Gestational diabetes mellitus (GDM) is characterized by maternal insulin resistance and hyperglycemia and has been associated with placental mitochondrial alterations. Small humanin-like peptides (SHLP1-6), encoded within the mitochondrial 16S rRNA region, have been described as mitochondria-derived peptides (MDPs) with reported cytoprotective and metabolic effects in experimental settings. However, their expression in placental tissues from GDM pregnancies has not been previously investigated. Methods: Placental tissues were obtained from women with GDM and normoglycemic controls following cesarean delivery. Maternal fasting glucose, fasting insulin, glycated hemoglobin A1c (HbA1c), and the homeostatic model assessment for insulin resistance (HOMA-IR) were recorded. Total RNA was isolated from placental samples, and the mRNA expression levels of Results: Placental expression levels of all six Conclusions: This study demonstrates that placental mRNA levels of
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