ArticleFrontiers in cell and developmental biology2026
Association of triglyceride glucose index and volumetric bone mineral density in T2DM: fat distribution as a potential indirect link.
Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Patients with type 2 diabetes mellitus (T2DM) generally present with insulin resistance, central obesity, and increased risk of fragility fracture. But the factors contributing to impaired bone health in T2DM are still unclear. This study investigated the association between the triglyceride glucose index (TyG), a surrogate marker of insulin resistance, and volumetric bone mineral density (vBMD) in T2DM, with a particular focus on the potential role of fat distribution. Methods: In this cross-sectional study, 189 patients with T2DM underwent quantitative computed tomography to assess lumbar vBMD and abdominal fat distribution, including visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and the visceral-to-subcutaneous fat ratio (VSR). Participants were stratified by TyG tertiles. Spearman correlation analyses, multiple linear regression analyses, and mediation analyses were conducted to examine the associations among TyG, vBMD and fat distribution parameters. Results: Higher TyG correlated with a worse fat distribution pattern and lower vBMD. In the fully adjusted model, each unit increase in TyG was associated with a 10.420 mg/cm Conclusion: Elevated TyG is associated with lower vBMD in patients with T2DM, and this association is consistent with a possible indirect link through fat distribution, especially VSR. TyG may serve as a simple and cost-effective marker to identify impaired bone health in T2DM, while targeting unhealthy fat distribution may have potential value in preventing diabetic osteoporosis.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.