Evidence map›Paper›PMID 42453151›Full record

ArticleFrontiers in aging neuroscience2026

Age-associated microglial heterogeneity includes emergence of mobile microglial states.

Sunitha Subhramanian, Olga Bocharova, Olga Mychko, Natallia Makarava, Ilia V Baskakov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sunitha SubhramanianDepartment of Neurobiology, University of Maryland School of Medicine, Baltimore, MD, United States.
Olga BocharovaDepartment of Neurobiology, University of Maryland School of Medicine, Baltimore, MD, United States.
Olga MychkoDepartment of Neurobiology, University of Maryland School of Medicine, Baltimore, MD, United States.
Natallia MakaravaDepartment of Neurobiology, University of Maryland School of Medicine, Baltimore, MD, United States.
Ilia V BaskakovDepartment of Neurobiology, University of Maryland School of Medicine, Baltimore, MD, United States.

Funding

Self-Propagating Mechanism of Prion DiseasesR01NS045585 · NINDS · UNIVERSITY OF MD BIOTECHNOLOGY INSTITUTE · PI Ilia V Baskakov · 2003 to 2026
$9.6M
Role of reactive astrocytes in prion diseasesR01NS129502 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI Ilia V Baskakov · 2023 to 2026
$2.5M
NINDS NIH HHS R01 NS045585NINDS NIH HHS R01 NS129502
6 · The paper itself

Abstract

Microglia maintain neuronal homeostasis through dynamic surveillance strategies that depend on their functional state. In the healthy brain, highly ramified microglia monitor neuronal integrity via motile processes and transient soma contacts. Aging is associated with reduced process motility and diminished expression of homeostatic markers, raising the question of how microglial surveillance adapts to these changes. Here, we used

Indexed as

agingcalciummicrogliamicroglial surveillancemobilityP2y12prion diseasestime-lapse imaging

Identifiers

PMID42453151
PMCPMC13365027

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.