ArticleJGH open : an open access journal of gastroenterology and hepatology2026
Investigating the Association Between Cystic Fibrosis and Colorectal Neoplasia: A Matched Case-Control Study.
Article in JGH open : an open access journal of gastroenterology and hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
9 authors.
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Abstract
Background: Cystic fibrosis (CF) is an autosomal recessive disorder that has been associated with increased risk of colorectal neoplasia and cancer (CRC). Current consensus statements recommend early screening and surveillance colonoscopies for CRC in CF, though high-quality data supporting this remains lacking. Methods: We performed a retrospective case-control study in a statewide CF referral center, comparing patients with CF and matched controls who underwent elective colonoscopy between 2010 and 2024. Results: Two hundred and forty-five patients with CF were included and matched 1:1 to control cohort. Significantly higher number of patients in CF cohort had neoplastic lesions (51.8% vs. 24.1%, OR 3.41, 95%-CI 2.32-5.02, Conclusions: This study highlights the increased association of CF with colorectal neoplasia and CRC, and the need for careful screening and surveillance via colonoscopy.
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