Evidence map›Paper›PMID 42453499›Full record

ReviewFrontiers in endocrinology2026

Vitamin D in the UK: an urgent call to redefine the threshold for deficiency.

Samantha Christie, Suma Uday, Thomas R Hill, Jonathan M Rhodes, Christopher T Sempos, Carrie H S Ruxton, Martin Hewison

Abstract readReview
In one paragraph

Review in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Samantha ChristieGreenwich Integrated Health, London, United Kingdom.
Suma UdayBirmingham Women's and Children's Hospital, Birmingham, United Kingdom.
Thomas R HillHuman Nutrition and Exercise Research Centre, Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.
Jonathan M RhodesMolecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, United Kingdom.
Christopher T SemposVitamin D Standardization Program, Havre de Grace, MD, United States.
Carrie H S RuxtonNutrition Communications, Cupar, United Kingdom.
Martin HewisonDepartment of Metabolism and Systems Science, University of Birmingham, Birmingham, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ACT NOW Vitamin D is a multidisciplinary collective tackling persistent public health concerns in the UK, including widespread vitamin D deficiency, nutritional rickets in children, and osteomalacia across the lifespan. National Diet and Nutrition Survey data show significant declines in vitamin D intake - especially among lower intake percentiles - and rising rates of severe vitamin D deficiency (serum 25-hydroxyvitamin D <25 nmol/L) among people aged 4-64 years. Contributing factors include reduced meat, fish and seafood consumption, increasing obesity, and growing high-risk ethnic minority population groups. However, the current UK biochemical definition of vitamin D deficiency (<25 nmol/L), as defined by the Scientific Advisory Committee on Nutrition (SACN 2016), may underestimate the broader scale of population risk and obscure the clinical burden described above. This position statement therefore makes the case for UK policymakers to adopt a higher threshold for vitamin D deficiency than the current <25 nmol/L recommended by SACN 2016. Raising the threshold to <50 nmol/L would bring the UK into closer alignment with international and clinical practice frameworks and may enable a broader and preventive approach to surveillance of national vitamin D status. Such reclassification would also provide a stronger evidential basis for policy review aimed at improving population-level "Vitamin D Health".

Indexed as

Vitamin DVitamin D DeficiencyAdolescentAdultChildChild, PreschoolHumansMiddle AgedNutrition SurveysRicketsUnited Kingdom25-hydroxyvitamin DVitamin DdeficiencynutritionosteomalaciaricketsthresholdUKvitamin D

Identifiers

PMID42453499
PMCPMC13364595

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.