ArticleCurrent stem cell reports2026
Genomic Instability and Clonal Hematopoiesis in the Deep-Space Environment: The Role of Sex-Chromosome Asymmetry and High-LET Radiation.
Article in Current stem cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
14 authors.
Funding
Abstract
Purpose of Review: This paper examines how deep-space conditions in the Artemis program, including radiation, microgravity, and other stressors affect genomic stability in blood-forming cells, with a focus on clonal hematopoiesis and sex-specific differences in DNA repair and mutation risk. Recent Findings: Studies show space conditions promote mutations in hematopoietic stem cells, with sex-specific effects: males are more vulnerable to Y chromosome loss and structural damage, while females may experience increased epigenetic instability despite protective redundancy from the X chromosome; these risks are amplified by combined stressors like radiation, oxidative stress, and circadian disruption. Summary: Sex chromosome differences play a key role in radiation-induced mutations and clonal expansion, highlighting the need for personalized, sex-specific medical monitoring and countermeasures rather than a uniform approach for astronauts on long-duration missions.
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Registered trials
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