Evidence map›Paper›PMID 42453649›Full record

ReviewTherapeutic advances in medical oncology2026

Driving precision medicine in testicular germ cell tumors: from preclinical models to clinical applications.

Nuno Tiago Tavares, Michelle Y Liu, Rui Henrique, Carmen Jerónimo, Robert S Weiss, João Lobo

Abstract readReview
In one paragraph

Review in Therapeutic advances in medical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nuno Tiago TavaresCancer Biology and Epigenetics Group, IPO Porto Research Center (CI-IPO Porto), Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal.
Michelle Y LiuDepartment of Biomedical and Translational Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
Rui HenriqueCancer Biology and Epigenetics Group, IPO Porto Research Center (CI-IPO Porto), Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal.
Carmen JerónimoCancer Biology and Epigenetics Group, IPO Porto Research Center (CI-IPO Porto), Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal.ORCID https://orcid.org/0000-0003-4186-5345
Robert S WeissDepartment of Biomedical and Translational Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.ORCID https://orcid.org/0000-0003-3327-1379
João LoboCancer Biology and Epigenetics Group, IPO Porto Research Center (CI-IPO Porto), Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal.ORCID https://orcid.org/0000-0001-6829-1391

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Testicular cancer is the most common cancer in young adult men, and its incidence is increasing globally, with testicular germ cell tumors (TGCT) being the most frequent subtype. These tumors show remarkable sensitivity to cisplatin, but there is a small subset of patients that develop resistance to the therapy, experiencing low quality of life and having no treatment options. Nowadays, there are a number of models that are useful for studying TGCT tumorigenesis and identifying novel targeted therapies for these patients. Thus, in this review, we aim to provide a comprehensive overview of the in vitro and in vivo TGCT models that are currently available, and also to summarize the main findings that have been made in the last years regarding preclinical and clinical studies of novel targeted therapies in TGCT patients.

Indexed as

clinical studiesin vitro modelsin vivo modelspreclinical studiestesticular germ cell tumorstranslational research

Identifiers

PMID42453649
PMCPMC13365679

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.