ArticleFrontiers in cardiovascular medicine2026
Relationship between persistent atrial fibrillation in high-altitude regions and left atrial diameter, red cell distribution width, and NT-ProBNP: a retrospective case-control study.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aimed to examine the association of left atrial diameter (LAD), red cell distribution width (RDW-CV) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) with persistent atrial fibrillation (AF) in high-altitude. Methods: In this retrospective study, a total of 4,244 patients diagnosed with persistent AF at Qinghai Province Cardiovascular and Cerebrovascular Disease Specialist Hospital between January 2019 and June 2021 were included in the AF group, and 883 healthy individuals were selected as the control group. Factors associated with AF were evaluated. The AF group was stratified into middle-altitude and high-altitude groups. Comparisons of cardiac structural parameters and hematological indicators were performed across ethnic and altitude groups. Results: LAD, N-terminal pro-B-type natriuretic peptide (NT-proBNP), and the coefficient of variation of RDW (RDW-CV) were identified as independent factors associated with AF [odds ratio (OR), 95% confidence interval (CI) = 1.014-1.241, 1.002-1.010, 1.282-1.655; Conclusion: LAD, NT-proBNP, and RDW-CV were factors associated with AF. LAD has a consistent association on patients with atrial fibrillation across different altitudes and ethnic groups.
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