ArticleRSC advances2026
Optimization of Xiaoer Lingyin granule formulation using single-factor and response surface methodology.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
This study aimed to develop and optimize Xiaoer Lingyin granules (XLGs), a pediatric traditional Chinese medicine formulation for acute pharyngitis, by integrating single-factor experiments, multi-index quality evaluation, and response surface methodology (RSM). Key formulation and process variables, including drug-to-excipient ratio, ethanol concentration, ethanol dosage, drying temperature, and drying time, were systematically evaluated to improve granule formability, flowability, dissolution performance, and palatability. The optimized formulation consisted of a drug-to-excipient ratio of 1 : 1, 65% (v/v) ethanol, 22.5% ethanol dosage, drying at 70 °C for 60 min, 0.2% sucralose, and 0.8% strawberry flavoring. Under these conditions, the granules showed high molding ratios, acceptable flowability, and dissolution ratios of ≥79.76%. The RSM model exhibited good predictive reliability, as confirmed by ANOVA, lack-of-fit analysis,
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