ReviewFrontiers in veterinary science2026
Ferroptosis in bovine mastitis: multidimensional mechanisms, stratified assessment, and intervention prospects.
Review in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Mastitis remains a major constraint on dairy cow health and production efficiency. Even after pathogen clearance, inflammation, epithelial injury, and lactation impairment can persist, indicating that disease outcome is not determined solely by pathogen burden. Ferroptosis, a regulated form of cell death driven by iron-dependent membrane phospholipid peroxidation, provides a mechanistic framework that links iron dyshomeostasis, oxidative injury, and irreversible tissue damage. Current evidence suggests that increased oxidative load, altered iron flux, restriction of the cysteine-glutathione (GSH)-glutathione peroxidase 4 (GPX4) axis, and remodeling of the membrane-lipid substrate pool can jointly lower the ferroptotic threshold of mammary epithelial cells in the mastitic microenvironment. Within defined pathogen contexts and temporal windows, oxidized lipids and damage-associated molecular patterns (DAMPs) may further contribute to inflammatory amplification, blood-milk barrier disruption, and lactation decline. However, direct
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