ReviewExtracellular vesicles and circulating nucleic acids2026
Advances in microbial extracellular vesicles: synthetic biology platforms and medical applications.
Review in Extracellular vesicles and circulating nucleic acids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Gram-Positive and Gram-Negative Probiotic Extracellular Vesicles: Mechanisms of Immune Modulation and Therapeutic Opportunities in Atopic Dermatitis.Clinical reviews in allergy & immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extracellular vesicles (EVs), typically ranging from 20 to 400 nanometers in diameter, are membrane-bound structures released into the extracellular environment by bacteria via specific secretion mechanisms. Consequently, these vesicles play a crucial role in bacterial physiological regulation and communication with hosts. Compared with EVs derived from plants and animals, Microbial extracellular vesicles (MEVs) offer distinct advantages, including lower production costs, higher yields, and greater abundance. This review outlines the biogenesis and release mechanisms of MEVs, and highlights how synthetic biology tools and platforms can be leveraged to engineer these vesicles, such as enhancing their production, modifying their cargo, and tailoring their surface properties. Furthermore, this article examines the promising biomedical applications of engineered MEVs, including targeted drug delivery, immune and inflammatory modulation, the discovery of disease biomarkers and therapeutic development. However, clinical translation of MEVs faces considerable challenges, primarily due to the lack of standardized, universally applicable isolation and purification protocols. This review therefore summarises contemporary extraction methods, functional characteristics and applications of MEVs alongside examples of recent MEV modifications. Ultimately, this work aims to bridge existing knowledge gaps and facilitate the development of MEV-based therapeutic strategies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.