ArticlePulmonary circulation2026
Minimally Invasive Porcine Model for Chronic Thromboembolic Pulmonary Hypertension.
Article in Pulmonary circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Minimally Invasive Porcine Model for Chronic Thromboembolic Pulmonary Hypertension.Pulmonary circulation · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To elucidate the complex pathophysiology of chronic thromboembolic pulmonary hypertension (CTEPH), a disease associated with bilateral fibrotic obstructions of the pulmonary arteries (PA) and microvascular changes, research relies on animal models, which often depend on invasive techniques, including open surgery. As animal welfare is a major priority for the future of experimental research, and in accordance with the principles of the 3Rs (Replacement, Reduction, and Refinement), this project aimed to develop a fully minimally invasive porcine CTEPH model. In five female large white pigs (50 kg, 3-4 months), an intravascular plug was inserted into the left PA. The right lower lobe artery was embolized weekly for 5 weeks with non-resolving n-butyl-2-cyanoacrylate-glue. Magnetic resonance imaging (MRI) was performed at each intervention. At week 6, plasma molecular and macro- and microscopic analyses were performed. Implantation of the intravascular plug was successful in all animals, without any residual perfusion seen in MRI angiography. Significant increases in mean pulmonary artery pressure (mPAP) (
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