ArticleAmerican journal of physiology. Endocrinology and metabolism2026
Differential impact of cancer- and chemotherapy-induced cachexia: a comparative analysis in a preclinical model of colorectal cancer by biological sex.
Ana Regina Cabrera, Eleanor R Schrems, Ruqaiza Muhyudin, Francielly Morena, Stavroula Tsitkanou, Ronald G Jones, Kaitlyn Parker, Morghan Relich, Kevin A Murach, Timothy J Muldoon and 2 more
Abstract readComparative Study
In one paragraphArticle in American journal of physiology. Endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
12 authors.
Ana Regina CabreraCachexia Research Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, Arkansas, United States.ORCID 0000-0002-9811-3585 Eleanor R SchremsExercise Muscle Biology Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, Arkansas, United States.ORCID 0009-0008-1264-5064 Ruqaiza MuhyudinCachexia Research Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, Arkansas, United States.
Francielly MorenaCachexia Research Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, Arkansas, United States.ORCID 0000-0001-5019-2125 Stavroula TsitkanouCachexia Research Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, Arkansas, United States.ORCID 0000-0002-6753-5945 Ronald G JonesMolecular Muscle Mass Regulation Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, Arkansas, United States.
Kaitlyn ParkerCachexia Research Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, Arkansas, United States.
Morghan RelichDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, Arkansas, United States.
Kevin A MurachMolecular Muscle Mass Regulation Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, Arkansas, United States.ORCID 0000-0003-2783-7137 Timothy J MuldoonDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, Arkansas, United States.
Tyrone A WashingtonExercise Muscle Biology Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, Arkansas, United States.ORCID 0000-0002-1919-5907 Nicholas P GreeneCachexia Research Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, Arkansas, United States.ORCID 0000-0001-9621-2005 Funding
The role of autophagy in bone remodelingP20GM125503 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · 2023 to 2025
$6.8MHHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) R01AR075794-01A1/AR/NIAMS (NPG)HHS | NIH | National Institute of General Medical Sciences (NIGMS) P20GM125503NIAMS NIH HHS R01 AR075794NIGMS NIH HHS P20 GM125503
6 · The paper itselfAbstract
Cancer cachexia is a wasting condition characterized by muscle loss and reduced quality of life in cancer patients. Although biological sex differences in the progression of cancer cachexia have been increasingly recognized, their role during chemotherapy-treated cancer cachexia remains largely unexplored. We evaluated such potential differences in male and female mice implanted subcutaneously with Colon-26 (C26) allografts. Our novel approach to disentangle the effects of chemotherapy consisted of administering two cycles of 75% of the maximum tolerated dose of 5-fluorouracil, cisplatin, or paclitaxel in the presence and absence of cancer (
Indexed as
Antineoplastic AgentsCachexiaColorectal NeoplasmsAnimalsBody WeightCell Line, TumorCisplatinDisease Models, AnimalFemaleFluorouracilMaleMiceMuscle, SkeletalPaclitaxelSex CharacteristicsSex FactorsAntineoplastic AgentsCisplatinFluorouracilPaclitaxel5-fluorouracilatrophycisplatinpaclitaxelprotein processing
Identifiers
PMID42454521
PMCPMC13439732
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