Evidence map›Paper›PMID 42454686›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Triple-Microenvironment Decoding Enables Logic-Unlocked Precision Photoimmunotherapy.

Chuangjun Liu, Yu Liu, Simin Liang, Yingchun Jiang, Hai Yi, Xueping Diao, Na Li, Bin Zhang, Miao Yu, Rongqiang Li and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Chuangjun LiuCollege of Chemistry and Pharmaceutical Engineering, Huanghuai University, Zhumadian, China.
Yu LiuKey Laboratory of Biomedical Imaging Science and System, Chinese Academy of Sciences, State Key Laboratory of Biomedical Imaging Science and System, Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab For Biomaterials, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Simin LiangDepartment of Medical Ultrasound, Laboratory of Novel Optoacoustic (Ultrasonic) Imaging, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Yingchun JiangCollege of Chemistry and Pharmaceutical Engineering, Huanghuai University, Zhumadian, China.
Hai YiCollege of Chemistry and Pharmaceutical Engineering, Huanghuai University, Zhumadian, China.
Xueping DiaoCollege of Chemistry and Pharmaceutical Engineering, Huanghuai University, Zhumadian, China.
Na LiCollege of Chemistry and Pharmaceutical Engineering, Huanghuai University, Zhumadian, China.
Bin ZhangCollege of Chemistry and Pharmaceutical Engineering, Huanghuai University, Zhumadian, China.ORCID 0009-0006-1368-0131
Miao YuCollege of Chemistry and Pharmaceutical Engineering, Huanghuai University, Zhumadian, China.
Rongqiang LiCollege of Chemistry and Pharmaceutical Engineering, Huanghuai University, Zhumadian, China.
Michael N OkekeKey Laboratory of Biomedical Imaging Science and System, Chinese Academy of Sciences, State Key Laboratory of Biomedical Imaging Science and System, Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab For Biomaterials, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Kun QianState Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Qihang DingDepartment of Chemistry Korea University, Seoul, Republic of Korea.ORCID 0000-0002-2665-9036
Ping GongKey Laboratory of Biomedical Imaging Science and System, Chinese Academy of Sciences, State Key Laboratory of Biomedical Imaging Science and System, Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab For Biomaterials, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.ORCID 0000-0002-6687-0565
Zhen ChengState Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.ORCID 0000-0001-8177-9463
Chunbai XiangDepartment of Laboratory Medicine, Affiliated Qingyuan Hospital, Guangzhou Medical University (Qingyuan People's Hospital), Qingyuan, China.ORCID 0000-0002-1880-2816

Funding

Guangdong Provincial Natural Science Foundation 2024A1515010635National Key Research and Development Program of China 2021YFA0910000National Natural Science Foundation of China 22474152Science and Technology Development Plan of Henan Province 262102521019Scientific Research Foundation of Peking University Shenzhen Hospital KYQD2023289Scientific Research Startup Project for High-Level Introduced Talent at Qingyuan Hospital, Guangzhou Medical University QYRYRC2025009Strategic Priority Research Program of the Chinese Academy of Sciences XDB0830300Zhumadian City Biopharmaceutical Industry Joint Fund CY2523013
6 · The paper itself

Abstract

Achieving tumor-specific activation of pyroptosis and ferroptosis holds great promise for cancer immunotherapy, yet current photosensitizers (PSs) capable of such dual induction predominantly operate in an always-on manner and rely on visible-light excitation, limiting both precision and tissue penetration. Here, we report RPIB-Cys, a self-assembled triple-locked near-infrared (NIR) type-I PS that remains photoinactive until activated in the mitochondrial microenvironment of triple-negative breast cancer (TNBC). The molecule is intelligently engineered such that its photoactivity is restored only upon cooperative stimulation by elevated viscosity, alkaline pH, and high cysteine (Cys) levels, three hallmarks of cancer mitochondria. Unlocking simultaneously enables NIR fluorescence/photoacoustic (PA) imaging and efficient type-I reactive oxygen species (ROS) generation. The resulting photoinduced oxidative stress triggers ferroptosis via glutathione depletion and glutathione peroxidase 4 (GPX4) inactivation, while concurrently inducing pyroptosis through gasdermin D (GSDMD) cleavage. This spatially controlled dual immunogenic cell death (ICD) converts cold TNBC into inflamed tumors, representing a multiple‑response activatable type‑I PS that uniquely integrates multimodal imaging with the concurrent induction of pyroptosis and ferroptosis for precision photoimmunotherapy.

Indexed as

Antineoplastic AgentsImmunotherapyPhotosensitizing AgentsPhototherapyTumor MicroenvironmentAnimalsFerroptosisHumansMicePyroptosisReactive Oxygen SpeciesAntineoplastic AgentsPhotosensitizing AgentsReactive Oxygen Speciesferroptosismitochondriapyroptosistriple‐locked activationtype‐I photosensitizer

Identifiers

PMID42454686
PMCPMC13573032

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.