ArticleRevista da Associacao Medica Brasileira (1992)2026
Effect of patient and partner preconceptional nutraceutical supplementation on the onset of natural pregnancy: a retrospective study.
Article in Revista da Associacao Medica Brasileira (1992), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
backgroundInfertility affects 10-15% of couples worldwide. Although assisted reproductive technologies such as in vitro fertilization are effective, they are invasive, costly, and not without risks. Nutraceutical supplementation has gained importance as a non-invasive option to support natural conception.
objectiveThe aim of this study was to evaluate whether combined nutraceutical supplementation improves natural pregnancy rates in subfertile couples with a relative indication for in vitro fertilization while awaiting treatment.
methodsThis retrospective study included 213 couples followed for 6 months (119 in the supplementation group; 94 controls). In the treatment group, both partners received combined nutraceutical supplementation (PROfertil® female/male). Controls received folic acid for women only, while men received no treatment. All couples were on an in vitro fertilization waiting list without an absolute indication for immediate assisted reproductive technologies. Those with oligoasthenozoospermia II/III or bilateral tubal occlusion were excluded. The primary endpoint was a natural pregnancy within 6 months.
resultsNatural conception occurred more often in the supplementation group than in controls (66.4 vs. 39.4%, p<0.001). Multivariate logistic regression showed a 4.13-fold higher odds of pregnancy with supplementation (95%CI 2.12-8.04, p<0.001).
conclusionCombined nutraceutical supplementation significantly increased natural pregnancy rates in couples awaiting in vitro fertilization. Randomized trials are needed to confirm these findings and assess live birth outcomes.
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