ReviewTissue engineering and regenerative medicine2026
Electrical Stimulation-Induced Modulation of Small Extracellular Vesicles in Regenerative Therapy.
Review in Tissue engineering and regenerative medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
backgroundSmall extracellular vesicles (sEVs) are nanoscale, membrane-bound vesicles mediating intercellular communication by transferring bioactive molecules, including nucleic acids, proteins, lipids, and metabolites. Electrical stimulation (ES) has emerged as a bioengineering strategy for modulating cellular electrophysiology, calcium signaling, and vesicle secretion. Although ES is increasingly recognized as a regulator of sEV biology, its effects on sEV biogenesis, cargo composition, and regenerative function have not been systematically defined. Therefore, this review aims to synthesize current evidence to clarify the influence of ES on sEV biogenesis, release, cargo remodeling, and functional outcomes in regenerative contexts.
methodsRelevant published literature was reviewed to summarize current evidence on the effects of electrical stimulation on sEV biogenesis, secretion, cargo composition, and regenerative function. Articles were selected based on their relevance to ES-mediated sEV regulation, electrically responsive tissues, and regenerative medicine applications.
resultsThe reviewed studies indicate that ES can regulate sEV secretion and alter molecular cargo profiles in a context-dependent manner. Evidence from diverse electroresponsive tissue-related systems suggests that ES-modulated sEVs may contribute to regenerative and tissue-protective responses.
conclusionsThis review summarizes current evidence on ES-mediated sEV modulation across electroresponsive tissues. Given remaining challenges in standardization and in vivo mechanistic validation, we propose future directions including advanced EV tracking and cell-type-specific analyses. Overall, ES-enabled sEV modulation represents a promising strategy for next-generation regenerative therapies.
Indexed as
Identifiers
42455291What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.