Evidence map›Paper›PMID 42455337›Full record

ReviewSchmerz (Berlin, Germany)2026

[Transgender health, migraine and headache-Underestimated associations, limited data situation].

Armin Scheffler, Dagny Holle-Lee

Abstract readEnglish AbstractReview
PubMed Publisher
In one paragraph

Review in Schmerz (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Armin SchefflerWestdeutsches Kopfschmerzzentrum, Zentrum für Translationale Neuro- und Verhaltenswissenschaften (C-TNBS), Klinik für Neurologie, Universitätsklinikum Essen, Universität Duisburg-Essen, Hufelandstraße 55, 45147, Essen, Deutschland.
Dagny Holle-LeeWestdeutsches Kopfschmerzzentrum, Zentrum für Translationale Neuro- und Verhaltenswissenschaften (C-TNBS), Klinik für Neurologie, Universitätsklinikum Essen, Universität Duisburg-Essen, Hufelandstraße 55, 45147, Essen, Deutschland. dagny.holle-lee@uk-essen.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Migraine and other headache disorders are highly relevant in the care of transgender patients. Gender-affirming hormone therapies lead to adaptive changes in physiological systems that are typically sexually dimorphic, aligning them with an endocrine milieu corresponding to the affirmed gender. This can substantially influence hormone-dependent components of migraine, such as frequency, intensity and triggering mechanisms. In addition, psychosocial factors play an important role: transgender individuals are often exposed to specific stressors which, within the biopsychosocial model, can directly affect the experience of pain and migraine. The available data are currently very limited and their interpretation is further constrained by small cohorts, predominantly from uncontrolled studies as well as heterogeneous definitions of both headache disorders and the studied populations. Therefore, this article does not claim to be comprehensive but rather provides an overview of the challenges in transgender patients with migraine and other headache disorders.

Indexed as

Headache DisordersMigraine DisordersTransgender PersonsComorbidityCross-Sectional StudiesFemaleHumansMaleModels, BiopsychosocialBiopsychosocial model/painGender-affirming hormone therapyMigraine, estrogen-associatedMigraine prevalence/transgender personsPsychosocial stressors

Identifiers

PMID42455337

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.