Evidence map›Paper›PMID 42455372›Full record

ArticlePlanta2026

Harnessing genetic, chemical, and transcriptomic analyses guided the selection of Cistus creticus subsp. creticus genotypes rich in labdane-type diterpenes.

Stefanos Kostas, Symela Ntoanidou, Christos Bazakos, Eirini Sarrou, Nausica Rafailidou, Antigoni Papanikolaou, Antonios Makris, Aikaterini-Angeliki Kotoula, Efstathios Hatziloukas, Athanasios Economou and 1 more

Abstract read
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In one paragraph

Article in Planta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Stefanos KostasLaboratory of Floriculture, Department of Horticulture, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece. skostas@agro.auth.gr.ORCID http://orcid.org/0000-0002-9653-5020
Symela NtoanidouGroup of Biotechnology of Pharmaceutical Plants, Laboratory of Pharmacognosy, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece. sntoa@pharm.auth.gr.ORCID http://orcid.org/0000-0003-2579-5084
Christos BazakosInstitute of Plant Breeding and Genetic Resources, ELGO-DIMITRA, Thessaloniki-Thermi, Greece.
Eirini SarrouInstitute of Plant Breeding and Genetic Resources, ELGO-DIMITRA, Thessaloniki-Thermi, Greece.
Nausica RafailidouGroup of Biotechnology of Pharmaceutical Plants, Laboratory of Pharmacognosy, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece.
Antigoni PapanikolaouGroup of Biotechnology of Pharmaceutical Plants, Laboratory of Pharmacognosy, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece.
Antonios MakrisInstitute of Applied Biosciences, Centre for Research and Technology Hellas (INAB-CERTH), P.O. Box 60361, Thermi, 57001, Thessaloniki, Greece.
Aikaterini-Angeliki KotoulaLaboratory of Floriculture, Department of Horticulture, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece.
Efstathios HatziloukasLaboratory of Molecular Biology and Genetics, Department of Biological Applications and Technologies, University of Ioannina, 45110, Ioannina, Greece.
Athanasios EconomouLaboratory of Floriculture, Department of Horticulture, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece.
Angelos K KanellisGroup of Biotechnology of Pharmaceutical Plants, Laboratory of Pharmacognosy, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece. kanellis@pharm.auth.gr.ORCID http://orcid.org/0000-0002-7653-440X

Funding

RESEARCH-CREATE-INNOVATE T1EDK-03919
6 · The paper itself

Abstract

MAIN

conclusionThe present study connects the genetic diversity of Cistus creticus to its chemical profile, identifying elite genotypes and key biosynthetic genes for enhancing the production of valuable labdane diterpenes. Cistus creticus, a Mediterranean shrub, is known for its resin ladano, which is rich in pharmacologically active labdane-related diterpenes (LRDs). However, the genetic and molecular basis for the LRDs content variation among natural populations remains uncharacterized. This study aims to fulfill this lacuna by investigating a potential link between genetic diversity and chemotypic profile across 91 genotypes from seven different populations across Greece and identifying elite germplasm by uncovering the molecular and regulatory mechanisms underlying LRDs biosynthesis. The genetic analysis, employing ISSR markers, revealed significant genetic differentiation among populations (Φ

Indexed as

CistusDiterpenesGene Expression ProfilingGene Expression Regulation, PlantGenetic VariationGenotypeGreeceTranscriptomeDiterpeneslabdaneGC–MSGene expressionISSRLadanoMolecular markers

Identifiers

PMID42455372
PMCPMC13372853

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.