Evidence map›Paper›PMID 42455402›Full record

ReviewMolecular biology reports2026

How to recognize if a cell dies from pyroptosis?

Michał Gebuza, Weronika Bihl, Kinga Brawańska-Maśluch, Paulina Tomecka, Marek Kulbacki, Julita Kulbacka

Abstract readReview
In one paragraph

Review in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michał Gebuza *Department and Clinic of Ophthalmology, Medical University Hospital, Borowska 213, Wrocław, 50-556, Poland.
Weronika BihlLower Silesian Centre for Oncology, Pulmonology and Hematology, Plac Ludwika Hirszfelda 12, Wrocław, 53-413, Poland.
Kinga Brawańska-MaśluchDepartment of Physiology, Faculty of Physiology and Pathophysiology, Medical University of Wrocław, Wrocław, Poland.
Paulina TomeckaMedical University Hospital, Borowska 213, Wrocław, 50-556, Poland.
Marek KulbackiPolish-Japanese Academy of Information Technology, Koszykowa 86, Warsaw, 02- 008, Poland.
Julita Kulbacka *Department of Molecular and Cellular Biology, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, Wroclaw, 50-556, Poland. julita.kulbacka@umw.edu.pl.ORCID https://orcid.org/0000-0001-8272-5440

Funding

Uniwersytet Medyczny im. Piastów Slaskich we Wroclawiu No.: SUBZ.D260.25.027.
6 · The paper itself

Abstract

Pyroptosis is a distinct form of programmed cell death and plays a crucial role in immune processes by eliminating pathogens. It is mediated by the inflammasome pathway and is characterized by the release of proinflammatory cytokines. Distinguishing pyroptosis from other forms of programmed cell death, such as apoptosis and necroptosis, is essential for understanding its biological function in various physiological and pathological processes. In cancer development, pyroptosis has a dual role. Depending on the context and proper stimulation, it can either promote tumor growth and progression or lead to tumor destruction and suppression. The detection of pyroptosis-related molecules can serve as prognostic indicators and potential therapeutic targets across various treatment modalities. This review presents the methods and key factors involved in deciphering the occurrence of pyroptosis in cells, offering valuable insights into its role in diverse biological processes and clinical applications.

Indexed as

NeoplasmsPyroptosisAnimalsApoptosisCell DeathCytokinesHumansInflammasomesNecroptosisSignal TransductionCytokinesInflammasomesCancer cellsCanonical pathwayCell deathNoncanonical pathwayProgrammed cell deathPyroptosis

Identifiers

PMID42455402
PMCPMC13372845

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.