Evidence map›Paper›PMID 42455463›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026

Carnosine-Related Metabolism in Rat Cardiomyocytes and Human Heart Tissue.

Jade V Creighton, Lívia de Souza Gonçalves, Saulo Gil, Bianca Scigliano Vargas, Leonardo Jensen, Marisa Helena Gennari de Medeiros, Hamilton Roschel, Mark D Turner, Craig L Doig, Guilherme Giannini Artioli and 1 more

Abstract read
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In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jade V CreightonCentre for Systems Health and Integrated Metabolic Research (SHiMR), School of Science and Technology, Nottingham Trent University, Nottingham, UK.ORCID https://orcid.org/0000-0002-5521-7392
Lívia de Souza GonçalvesDepartment of Pediatrics, Division of Pediatric, University of California, San Francisco, California, USA.
Saulo GilApplied Physiology & Nutrition Research Group, School of Physical Education and Sport, Faculdade de Medicina, Divisão de Reumatologia, Universidade de São Paulo, São Paulo, Brazil.
Bianca Scigliano VargasDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil.
Leonardo JensenLaboratorio de Hipertensao do Instituto do Coraçao do Hospital das Clínicas da Faculdade de Medicina da Universidade São Paulo, São Paulo, Brazil.
Marisa Helena Gennari de MedeirosDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil.
Hamilton RoschelApplied Physiology & Nutrition Research Group, School of Physical Education and Sport, Faculdade de Medicina, Divisão de Reumatologia, Universidade de São Paulo, São Paulo, Brazil.
Mark D TurnerCentre for Systems Health and Integrated Metabolic Research (SHiMR), School of Science and Technology, Nottingham Trent University, Nottingham, UK.
Craig L DoigCentre for Systems Health and Integrated Metabolic Research (SHiMR), School of Science and Technology, Nottingham Trent University, Nottingham, UK.
Guilherme Giannini ArtioliApplied Physiology & Nutrition Research Group, School of Physical Education and Sport, Faculdade de Medicina, Divisão de Reumatologia, Universidade de São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-8463-2213
Craig SaleDepartment of Sport and Exercise Sciences, Manchester Metropolitan University Institute of Sport, Manchester, UK.ORCID https://orcid.org/0000-0002-5816-4169

Funding

Natural Alternatives InternationalSao Paulo Research Foundation (FAPESP) 2014/11948-8Sao Paulo Research Foundation (FAPESP) 2019/25032-9Sao Paulo Research Foundation (FAPESP) 2023/15629-3Sao Paulo Research Foundation (FAPESP) 2024/18769-3
6 · The paper itself

Abstract

The therapeutic potential of carnosine in healthy and diseased heart models is promising; however, the understanding of carnosine and β-alanine metabolism in cardiac tissue is lacking. Exploring how these compounds are metabolized in cardiac tissue is critical to determine their viability for in vivo supplementation studies. Two independent studies were conducted. Study 1 investigated the uptake of exogenous carnosine and β-alanine in cardiomyocytes and the influence of this on the expression of carnosine- and β-alanine-related enzyme and transporter genes. Study 2 investigated whether human cardiac tissue expresses carnosine and β-alanine metabolism proteins and the endogenous concentrations of carnosine and β-alanine. In Study 1, differentiated H9c2 cells were treated with 0.1-10.0 mM of carnosine or β-alanine for 4, 24 and 72 h. Gene expression was measured at 4 h using real-time quantitative polymerase chain reaction, and amino acid and histidine-containing dipeptides (HCD) concentrations were analyzed at all-time points using an amino acid analyzer. In Study 2, post-mortem human heart ventricle samples (n = 16) were analyzed for carnosine and β-alanine using HPLC-ESI

Indexed as

CarnosineMyocardiumMyocytes, CardiacAnimalsbeta-AlanineCell LineFemaleHumansMaleRatsbeta-AlanineCarnosinebeta‐alaninehistidine‐containing dipeptideshumanmyocardiumtaurine

Identifiers

PMID42455463
PMCPMC13371992

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.