Evidence map›Paper›PMID 42455917›Full record

ArticleDrug development research2026

Discovery of a Potent and Selective MAO-B Inhibitor From a Donepezil-Linked Chalcone Library With Promising Antiparkinsonian Activity.

Azize Kirac-Aydin, Bishnu Prasad Pandey, Satyajit Mohanty, Rupsa Mondal, Abanish Biswas, Ashok Kumar Pattnaik, Subodh Mondal, Vinay N Basavanakatti, Nilüfer Bayrak, Venkatesan Jayaprakash and 2 more

Abstract read
In one paragraph

Article in Drug development research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Azize Kirac-AydinDepartment of Chemistry, Faculty of Science, Istanbul University, Istanbul, Türkiye.
Bishnu Prasad PandeyDepartment of Pharmacy, College of Pharmacy, Sunchon National University, Suncheon, Republic of Korea.ORCID https://orcid.org/0000-0002-3244-8796
Satyajit MohantyDepartment of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Ranchi, India.
Rupsa MondalDepartment of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Ranchi, India.
Abanish BiswasDepartment of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Ranchi, India.
Ashok Kumar PattnaikDepartment of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Ranchi, India.
Subodh MondalBioanalysis, Eurofins Advinus Biopharma Services India Pvt. Ltd, Bengaluru, India.
Vinay N BasavanakattiAdgyl Lifesciences Private Limited, Bengaluru, India.
Nilüfer BayrakDepartment of Chemistry, Faculty of Science, Istanbul University, Istanbul, Türkiye.
Venkatesan JayaprakashDepartment of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Ranchi, India.
Hoon KimDepartment of Pharmacy, College of Pharmacy, Sunchon National University, Suncheon, Republic of Korea.
Amaç Fatih TuYuNDepartment of Chemistry, Faculty of Science, Istanbul University, Istanbul, Türkiye.ORCID https://orcid.org/0000-0001-5698-1109

Funding

The National Research Foundation of Korea (NRF) funded by the Korean Government RS-2024-00347522The Scientific Research Projects Coordination Unit of Istanbul University FDK-2024-40841
6 · The paper itself

Abstract

A focused library of 19 donepezil-linked chalcones (DLCs) was efficiently synthesised through microwave-assisted Claisen-Schmidt condensation and subsequently profiled for their inhibitory activities against cholinesterases (AChE and BuChE) as well as monoamine oxidases (MAO-A and MAO-B). The DLCs exhibited potent and selective inhibition of MAO-B, with IC

Indexed as

ChalconesDonepezilMonoamine Oxidase InhibitorsAnimalsCholinesterase InhibitorsDrug DiscoveryHumansMolecular Docking SimulationMonoamine OxidaseRatsStructure-Activity RelationshipChalconesCholinesterase InhibitorsDonepezilMonoamine OxidaseMonoamine Oxidase InhibitorsAlzheimer's diseasechalconescholinesterasekinetic studymolecular dockingmonoamine oxidasereversibility

Identifiers

PMID42455917
PMCPMC13372239

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.