Evidence map›Paper›PMID 42457670›Full record

ArticleTranslational psychiatry2026

Early-life adversity shapes anomalous spontaneous behavior in mice heterozygous for Cntnap2.

Viviana Canicatti, Vanes Cibin, Nicoletta Berardi, Yuri Bozzi, Alessandro Sale, Gabriele Chelini

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Article in Translational psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Viviana CanicattiInstitute of Neuroscience, National Council of Research, Pisa, Italy.
Vanes CibinCenter for Mind/Brain Sciences, University of Trento, Rovereto, Italy.
Nicoletta BerardiInstitute of Neuroscience, National Council of Research, Pisa, Italy.
Yuri BozziInstitute of Neuroscience, National Council of Research, Pisa, Italy.ORCID http://orcid.org/0000-0002-1496-9889
Alessandro SaleInstitute of Neuroscience, National Council of Research, Pisa, Italy.
Gabriele CheliniInstitute of Neuroscience, National Council of Research, Pisa, Italy. gabriele.chelini@unitn.it.ORCID http://orcid.org/0000-0001-6654-4332

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The influence of early-life experiences is widely acknowledged as a crafting tool that sculpts complex behavioral patterns and well-being of living organisms. The use of preclinical models can provide invaluable insight into how a negative environmental push interplays with genetic make-up in shaping psychiatric vulnerability. Recently, the development of automated tools to classify spontaneous behavior in mice has opened the possibility to investigate the impact of experimental manipulation onto the composition of naturalistic behavior. In this work, we applied a tool for digitalized ethological screening to identify spontaneous hallmarks of altered neurobehavioral functioning in a dual-hit mouse model. To do so, mice carrying heterozygous deletion of the gene coding for contactin-associated protein-like 2 (Cntnap2

Indexed as

Behavior, AnimalMembrane ProteinsNerve Tissue ProteinsAnimalsDisease Models, AnimalExploratory BehaviorFemaleHeterozygoteMaleMiceMice, Inbred C57BLCNTNAP2 protein, mouseMembrane ProteinsNerve Tissue Proteins

Identifiers

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.