ArticleNature communications2026
Orthogonal assembly of hetero-porous structures by reversible adaptation for efficient isomeric separation.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Isomers separation is a challenging but crucial process in biological and chemical processes. Mixed-matrix membranes (MMMs) combining selective adsorbents within the polymer matrix have the potential for separating isomeric mixtures. However, the limited compatibility is a significant problem for efficient separation with appropriate permeability and selectivity. Herein, we report the rational design and construction of a highly oriented multi-porous membrane by the orthogonal assembly of hydrogen-bonded macrocycle amphiphiles through dynamic adaptation. The macrocycles can undergo helical propagation in the vertical direction with hydrophilic exteriors, forming lyotropic liquid crystal gels. By simultaneous control of immiscible pores with identical hydrogen bonding, well-aligned chiral nanochannels are created in gel matrix, enabling precise molecular sieving with separation factor of 11.46 for constitutional isomer and 92% ee for enantiomer. The strategy follows the principle of dynamic chemistry, providing a versatile platform for energy-efficient separations in chiral resolution, fine chemical purification and biomimetic transport systems.
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