Evidence map›Paper›PMID 42457927›Full record

ArticleCell death and differentiation2026

DHRS9 generates crotonyl-CoA from butyryl-CoA to epigenetically regulate STING transcription and potentiate immune activation.

Yuling Zhang, Fei Qin, Jiajia Zhang, Xuemei Bai, Jiahua Yuan, Nan Cao, Na Dong, Min Zhou, Ziye He, Xiaoxiao Li and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Cell death and differentiation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yuling ZhangState Key Laboratory of Reproductive Medicine and Offspring Health, State Key Laboratory of Microbial Technology, Shandong Key Laboratory of Infection Immunity and Disease Intervention & Key Laboratory for Experimental Teratology of Ministry of Education, Shandong University, Jinan, Shandong, China.
Fei QinState Key Laboratory of Reproductive Medicine and Offspring Health, State Key Laboratory of Microbial Technology, Shandong Key Laboratory of Infection Immunity and Disease Intervention & Key Laboratory for Experimental Teratology of Ministry of Education, Shandong University, Jinan, Shandong, China.
Jiajia ZhangState Key Laboratory of Reproductive Medicine and Offspring Health, State Key Laboratory of Microbial Technology, Shandong Key Laboratory of Infection Immunity and Disease Intervention & Key Laboratory for Experimental Teratology of Ministry of Education, Shandong University, Jinan, Shandong, China.
Xuemei BaiState Key Laboratory of Reproductive Medicine and Offspring Health, State Key Laboratory of Microbial Technology, Shandong Key Laboratory of Infection Immunity and Disease Intervention & Key Laboratory for Experimental Teratology of Ministry of Education, Shandong University, Jinan, Shandong, China.
Jiahua YuanState Key Laboratory of Reproductive Medicine and Offspring Health, State Key Laboratory of Microbial Technology, Shandong Key Laboratory of Infection Immunity and Disease Intervention & Key Laboratory for Experimental Teratology of Ministry of Education, Shandong University, Jinan, Shandong, China.
Nan CaoState Key Laboratory of Reproductive Medicine and Offspring Health, State Key Laboratory of Microbial Technology, Shandong Key Laboratory of Infection Immunity and Disease Intervention & Key Laboratory for Experimental Teratology of Ministry of Education, Shandong University, Jinan, Shandong, China.
Na DongState Key Laboratory of Reproductive Medicine and Offspring Health, State Key Laboratory of Microbial Technology, Shandong Key Laboratory of Infection Immunity and Disease Intervention & Key Laboratory for Experimental Teratology of Ministry of Education, Shandong University, Jinan, Shandong, China.
Min ZhouState Key Laboratory of Reproductive Medicine and Offspring Health, State Key Laboratory of Microbial Technology, Shandong Key Laboratory of Infection Immunity and Disease Intervention & Key Laboratory for Experimental Teratology of Ministry of Education, Shandong University, Jinan, Shandong, China.
Ziye HeState Key Laboratory of Reproductive Medicine and Offspring Health, State Key Laboratory of Microbial Technology, Shandong Key Laboratory of Infection Immunity and Disease Intervention & Key Laboratory for Experimental Teratology of Ministry of Education, Shandong University, Jinan, Shandong, China.
Xiaoxiao LiState Key Laboratory of Reproductive Medicine and Offspring Health, State Key Laboratory of Microbial Technology, Shandong Key Laboratory of Infection Immunity and Disease Intervention & Key Laboratory for Experimental Teratology of Ministry of Education, Shandong University, Jinan, Shandong, China.
Huanming WangState Key Laboratory of Reproductive Medicine and Offspring Health, State Key Laboratory of Microbial Technology, Shandong Key Laboratory of Infection Immunity and Disease Intervention & Key Laboratory for Experimental Teratology of Ministry of Education, Shandong University, Jinan, Shandong, China.
Chengjiang GaoState Key Laboratory of Reproductive Medicine and Offspring Health, State Key Laboratory of Microbial Technology, Shandong Key Laboratory of Infection Immunity and Disease Intervention & Key Laboratory for Experimental Teratology of Ministry of Education, Shandong University, Jinan, Shandong, China. cgao@sdu.edu.cn.ORCID http://orcid.org/0000-0002-9365-4497
Bingyu LiuState Key Laboratory of Reproductive Medicine and Offspring Health, State Key Laboratory of Microbial Technology, Shandong Key Laboratory of Infection Immunity and Disease Intervention & Key Laboratory for Experimental Teratology of Ministry of Education, Shandong University, Jinan, Shandong, China. liubingyu@sdu.edu.cn.ORCID http://orcid.org/0000-0003-4817-5355

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32230033National Natural Science Foundation of China (National Science Foundation of China) 82321002
6 · The paper itself

Abstract

The stimulator of interferon genes (STING) pathway is a cornerstone of innate immunity and a promising therapeutic target for autoimmune diseases, inflammation, and cancer treatment. Lysine crotonylation, a recently discovered post-translational modification, regulates various cellular processes; however, its role in STING activation remains unclear. Here, we identified dehydrogenase/reductase (SDR family) member 9 (DHRS9) as a critical metabolic regulator of the STING signaling pathway. DHRS9 deficiency impaired activation of the cGAS-STING pathway, suppressed antiviral immunity against HSV-1, and exacerbated viral replication. Mechanistically, DHRS9 converts butyryl-CoA into crotonyl-CoA, thereby enhancing histone crotonylation (H3K14cr and H3K18cr) at the STING promoter to drive its transcription. AAV-mediated DHRS9 delivery significantly enhances antiviral and antitumor immunity, demonstrating its robust therapeutic potential. This study reveals a metabolic-epigenetic axis that regulates STING expression, offering new therapeutic strategies for immune-related diseases.

Identifiers

PMID42457927

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.