Evidence map›Paper›PMID 42457955›Full record

ArticleNature2026

Ketogenic diet mediates intestinal tumorigenesis through lipids not ketones.

Jessica E S Shay, Fangtao Chi, Constantine N Tzouanas, Shixun Han, Xiao Zhang, Johanna Ten Hoeve, Kevin J Williams, Seda Neptun, Tolga Sever, Isabela Fuentes and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jessica E S Shay *David H. Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-7799-1349
Fangtao Chi *David H. Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA. ftchi@mit.edu.ORCID http://orcid.org/0000-0002-5730-2830
Constantine N TzouanasDavid H. Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.
Shixun HanDavid H. Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.
Xiao ZhangDavid H. Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.ORCID http://orcid.org/0009-0001-0668-1076
Johanna Ten HoeveUCLA Metabolomics Center, Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, USA.
Kevin J WilliamsUCLA Lipidomics Core, University of California, Los Angeles, Los Angeles, CA, USA.
Seda NeptunDavid H. Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.
Tolga SeverDavid H. Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-0135-0243
Isabela FuentesDavid H. Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-2039-1737
Sangeeta N BhatiaDavid H. Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-1293-2097
Gizem Calibasi-KocalDavid H. Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.
Matthew G Vander HeidenDavid H. Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-6702-4192
Alex K ShalekDavid H. Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-5670-8778
Ömer H YilmazDavid H. Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA. ohyilmaz@mit.edu.ORCID http://orcid.org/0000-0002-7577-4612

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diet composition shapes tissue function and disease risk by modulating nutrient availability, metabolic state and cellular dynamics

Indexed as

CarcinogenesisDiet, KetogenicIntestinal NeoplasmsKetonesLipid MetabolismAdenomaAnimalsCell ProliferationDisease Models, AnimalFatty AcidsFemaleMaleMiceOxidation-ReductionStem CellsFatty AcidsKetones

Identifiers

PMID42457955

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.