ArticleBMC medical imaging2026
Quantitative CMR-derived pulmonary circulation imaging biomarkers in recent-onset dilated cardiomyopathy associated with pulmonary hemodynamics and clinical improvement.
Article in BMC medical imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
backgroundRecent-onset dilated cardiomyopathy (RODCM), defined as new DCM with heart failure (HF) symptoms appearing within six months, is a less documented form of HF. This study aims to evaluate pulmonary circulation imaging biomarkers (PCIB) obtained by cardiovascular magnetic resonance (CMR) in patients with RODCM to assess their association with pulmonary hypertension, systolic and diastolic function, and clinical improvement.
methodsNinety RODCM patients with baseline and one-year follow-up CMR, clinical examination, and transthoracic echocardiography were retrospectively included. Twenty-six were excluded following a myocarditis diagnosis confirmed by endomyocardial biopsy (EMB). PCIB (pulmonary transit time (PTT), corrected PTT (PTTc), pulmonary transit beats (PTB), and pulmonary blood volume index (PBVI)) were assessed using a first-pass perfusion CMR sequence. Pulmonary hypertension, diastolic, and systolic function were assessed. Correlations between PCIB and echocardiographic changes were analyzed. Patients were classified as responders/non-responders based on left ventricular ejection fraction (LVEF) improvement.
resultsFrom baseline to follow-up, LVEF increased (25% to 40%), while EDD (65 mm to 61 mm), sPAP (24.2 mmHg to 20.0 mmHg), and E/e' ratio (13 to 9) significantly reduced. Thirty-three patients were labeled as responders. PTT, PTTc, and PTB correlated with ΔE/e', diastolic function improvement, and ΔsPAP. PBVI correlated with ΔsPAP. PTB correlated with ΔNYHA class. The PCIB could not predict whether a patient would be a responder.
conclusionsThis study focused on PCIB as outcome predictors in patients with RODCM with EMB-excluded myocarditis. Our findings show that PTB and PTTc correlated with ΔE/e', diastolic function improvement, and ΔsPAP, while PTB additionally correlated with ΔNYHA class.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.