ArticleJournal of neuroinflammation2026
FPR2 deficiency alleviates LPS-induced depressive-like behaviors in mice by suppressing the microglial CSF1/NLRP3 inflammasome pathway.
Hanqi Wang, Yijun Chen, Junna Chang, Zhen Liu, Yang Yu
Abstract read
In one paragraphArticle in Journal of neuroinflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
5 authors.
Hanqi WangShanghai Frontiers Science Center of Drug Target Identification and Delivery, Engineering Research Center of Cell and Therapeutic Antibody, Ministry of Education, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, 200240, China.
Yijun ChenShanghai Frontiers Science Center of Drug Target Identification and Delivery, Engineering Research Center of Cell and Therapeutic Antibody, Ministry of Education, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, 200240, China.
Junna ChangShanghai Frontiers Science Center of Drug Target Identification and Delivery, Engineering Research Center of Cell and Therapeutic Antibody, Ministry of Education, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, 200240, China.
Zhen LiuShanghai Frontiers Science Center of Drug Target Identification and Delivery, Engineering Research Center of Cell and Therapeutic Antibody, Ministry of Education, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, 200240, China.
Yang YuShanghai Frontiers Science Center of Drug Target Identification and Delivery, Engineering Research Center of Cell and Therapeutic Antibody, Ministry of Education, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, 200240, China. yuyang2011@sjtu.edu.cn.
Funding
National Natural Science Foundation of China 81870835Natural Science Foundation of Shanghai 22ZR1434700
6 · The paper itselfAbstract
Depression is one of the most prevalent psychiatric disorders worldwide, yet its pathogenesis remains unclear. Here, we aimed to investigate the effects of formyl peptide receptor 2 (FPR2), a key regulator of innate immunity and inflammation, on lipopolysaccharide (LPS)-induced depression-related behaviors in mice after intraperitoneal administration, and to elucidate its regulatory mechanisms in microglia. FPR2 knockout (Fpr2
Indexed as
DepressionInflammasomesMicrogliaNLR Family, Pyrin Domain-Containing 3 ProteinReceptors, Formyl PeptideAnimalsLipopolysaccharidesMaleMiceMice, Inbred C57BLMice, KnockoutSignal Transductionformyl peptide receptor 2, mouseInflammasomesLipopolysaccharidesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseReceptors, Formyl PeptideAnxietyColony-stimulating factor 1 (CSF1)DepressionFormyl peptide receptor 2 (FPR2)Lipopolysaccharide (LPS)MicrogliaNeuroinflammationNOD-like receptor protein 3 (NLRP3)RNA sequencingSerum amyloid A (SAA)
Identifiers
PMID42458515
PMCPMC13656527
What Socratic holds
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