Evidence map›Paper›PMID 42458630›Full record

ArticleActa neuropathologica communications2026

Successful bioassay of blood from chronic wasting disease-affected cervids in cervid PrP transgenic Drosophila.

Alana M Thackray, Erin E McNulty, Amy V Nalls, Marcelo H Jorge, Michael J Chamberlain, Mark G Ruder, Candace K Mathiason, Raymond Bujdoso

Abstract read
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In one paragraph

Article in Acta neuropathologica communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alana M ThackrayDepartment of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK.
Erin E McNultyDepartment of Microbiology, Immunology and Pathology, Prion Research Center (PRC), Colorado State University, Fort Collins, CO, USA.
Amy V NallsDepartment of Microbiology, Immunology and Pathology, Prion Research Center (PRC), Colorado State University, Fort Collins, CO, USA.
Marcelo H JorgeWarnell School of Forestry and Natural Resources, University of Georgia, Athens, GA, USA.
Michael J ChamberlainWarnell School of Forestry and Natural Resources, University of Georgia, Athens, GA, USA.
Mark G RuderSoutheastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
Candace K MathiasonDepartment of Microbiology, Immunology and Pathology, Prion Research Center (PRC), Colorado State University, Fort Collins, CO, USA.
Raymond BujdosoDepartment of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK. rb202@cam.ac.uk.

Funding

Detection and Characterization of Blood-borne PrionsR01AI112956 · NIAID · COLORADO STATE UNIVERSITY · PI MATHIASON, CANDACE K. · 2014 to 2024
$4.6M
Biotechnology and Biological Sciences Research Council Grant BB/T00343X/1Multistate Conservation Grant Program through the Wildlife and Sport Fish Restoration Programs of the U.S. Fish and Wildlife Service Grant # F20AP00172National Institutes of Health / National Institute of Allergy and Infectious Diseases (NIH/NIAID) 2R01AI112956 and P01-AI-077774NIAID NIH HHS R01 AI112956
6 · The paper itself

Abstract

Chronic wasting disease is a fatal transmissible prion condition of free-ranging and farmed cervids including deer, elk, moose, muntjac and reindeer. Prionemia is a pathogenic feature of chronic wasting disease in cervids and underpins development of an ante-mortem blood test for effective disease management. To help achieve this goal, we show here that cervid PrP transgenic Drosophila can detect prion-infected blood from cervids with chronic wasting disease. We first established that cervid PrP Drosophila were highly sensitive to cervid prions since these flies were responsive to dilutions in the range of 10

Indexed as

Biological AssayDeerPrionsWasting Disease, ChronicAnimalsAnimals, Genetically ModifiedBrainDisease Models, AnimalDrosophilaFemalePrionsBloodChronic wasting diseaseDrosophilaInfectivityPre-clinicalPrionTransmissible

Identifiers

PMID42458630

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.