Evidence map›Paper›PMID 42458647›Full record

ArticleActa neuropathologica communications2026

Platelet transcriptomic signatures in pediatric brain tumors distinguish cancer from cancer-free control.

Markus Talka, Amanda Holmström, Jonathan Hiekka, Matti Kankainen, Satu Långström, Mia Westerholm-Ormio, Anu M Suominen, Ruth Nousiainen, Pirjo Isohanni, Pia Valle and 13 more

Abstract read
PubMed Publisher
In one paragraph

Article in Acta neuropathologica communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Markus Talka *Division of Genetics and Clinical Pharmacology, Diagnostic Center, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Amanda Holmström *Pediatric Research Center, Children's Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Jonathan HiekkaDivision of Genetics and Clinical Pharmacology, Diagnostic Center, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Matti KankainenDivision of Genetics and Clinical Pharmacology, Diagnostic Center, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Satu LångströmDivision of Hematology-Oncology and Stem Cell Transplantation, Children's Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Mia Westerholm-OrmioDivision of Pediatric Neurology, Children's Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Anu M SuominenDivision of Hematology-Oncology and Stem Cell Transplantation, Children's Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Ruth NousiainenPediatric Research Center, Children's Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Pirjo IsohanniDivision of Pediatric Neurology, Children's Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Pia ValleDivision of Hematology-Oncology and Stem Cell Transplantation, Children's Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Elina VälkesalmiPediatric Research Center, Children's Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Oskar SaijonmaaPediatric Research Center, Children's Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Atte KarppinenDepartment of Neurosurgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Päivi Koroknay-PalDepartment of Neurosurgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Anna Piippo-KarjalainenDepartment of Neurosurgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Jarno SatopääDepartment of Neurosurgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Nuutti VartiainenDepartment of Neurosurgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Jukka KanervaDivision of Hematology-Oncology and Stem Cell Transplantation, Children's Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Olli TynninenDepartment of Pathology, Diagnostic Center, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Soili KytöläDivision of Genetics and Clinical Pharmacology, Diagnostic Center, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Anna-Kaisa AnttonenDivision of Genetics and Clinical Pharmacology, Diagnostic Center, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Virve PentikäinenPediatric Research Center, Children's Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Katja ElorantaPediatric Research Center, Children's Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland. katja.eloranta@helsinki.fi.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malignant pediatric brain tumors remain the leading cause of cancer-related mortality in children. Current diagnostics and monitoring rely on imaging and invasive biopsy, which may not capture tumor heterogeneity. Liquid biopsy-based biomarkers offer a novel, minimally invasive option. Among these, tumor-educated platelets have shown diagnostic value in adult cancers, but their utility in pediatric brain tumors has not been investigated. We analyzed platelet transcriptomes of 73 blood samples from 23 pediatric brain tumor patients, classified as high-grade or low-grade tumor patients, and 25 cancer-free controls. Platelets were isolated, CD45

Indexed as

Blood PlateletsBrain NeoplasmsTranscriptomeAdolescentBiomarkers, TumorChildChild, PreschoolFemaleGene Expression ProfilingHumansInfantMaleBiomarkers, TumorCirculating biomarkersCNS tumorsLiquid biopsyPediatric brain tumorsPediatric cancersPlatelet transcriptomicsRNA sequencingTumor-educated platelets

Identifiers

PMID42458647

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.