Evidence map›Paper›PMID 42458757›Full record

ArticlePediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2026

Symptom probability increases at low pollen exposure in adolescents with allergic rhinitis findings from the GINIplus and LISA birth cohorts.

Jonas Schmid, Patricia Grill, Claudia Flexeder, Elisabeth Thiering, Jeroen Buters, Inga Weßels, Carsten Schmidt-Weber, Marie Standl, Viktoria Ocvirk

Abstract read
In one paragraph

Article in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Symptom probability increases at low pollen exposure in adolescents with allergic rhinitis findings from the GINIplus and LISA birth cohorts.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jonas SchmidInstitute of Epidemiology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany.ORCID https://orcid.org/0000-0001-5290-5360
Patricia GrillInstitute of Epidemiology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany.
Claudia FlexederInstitute of Epidemiology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany.
Elisabeth ThieringInstitute of Epidemiology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany.
Jeroen ButersCenter of Allergy & Environment (ZAUM), Member of the German Center for Lung Research (DZL), Technical University and Helmholtz Center Munich, Munich, Germany.
Inga WeßelsCenter of Allergy & Environment (ZAUM), Technical University and Helmholtz Center Munich, Munich, Germany.
Carsten Schmidt-WeberCenter of Allergy & Environment (ZAUM), Technical University and Helmholtz Center Munich, Munich, Germany.
Marie StandlInstitute of Epidemiology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany.ORCID https://orcid.org/0000-0002-5345-2049
Viktoria OcvirkInstitute of Epidemiology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany.

Funding

Bundesministerium für Forschung, Technologie und Raumfahrt (BMFTR) 01 EE 9401-4Bundesministerium für Forschung, Technologie und Raumfahrt (BMFTR) 01 EG 9705/2Bundesministerium für Forschung, Technologie und Raumfahrt (BMFTR) 01EG9732European Research Council 949906Seventh Framework Programme 261357Umweltbundesamt 20462296
6 · The paper itself

Abstract

backgroundPollen-induced allergic rhinitis increases significantly with age among children and adolescents and is associated with reduced quality of life due to symptom severity, social impacts, and decreased school performance. This study examines associations between pollen exposure and allergic rhinitis symptoms in German adolescents.

methodsIn the 15-year follow-up of the GINIplus and LISA birth cohorts at the Munich study area, monthly occurrence of nasal symptoms was assessed in 1594 participants. Pollen concentrations of birch, grass, ragweed, and mugwort between January 2010 and March 2014 were considered. Monthly individual pollen exposures (grains/m

resultsA non-linear association between individual pollen exposure and nasal symptoms was observed, with symptom probability increasing significantly at low pollen concentrations and plateauing around 24 grains/m

conclusionEven at low pollen concentrations, there is an increase in symptom probability of seasonal allergic rhinitis that remains elevated at high pollen concentrations in sensitized participants. Enhanced probability rates also remain in late seasons after the pollen peak. These findings show that allergic rhinitis patients cannot rely on high-pollen warnings but require accurate measurements to avoid exposure and allergic symptoms.

Indexed as

AllergensEnvironmental ExposurePollenRhinitis, AllergicRhinitis, Allergic, SeasonalAdolescentBetulaBirth CohortChildFemaleFollow-Up StudiesGermanyHumansMalePoaceaeProbabilityAllergensadolescentsallergic rhinitisbirth cohortepidemiologypollenpollen allergy symptomsseasonal allergic rhinitis

Identifiers

PMID42458757
PMCPMC13373345

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.