ArticleLiver international : official journal of the International Association for the Study of the Liver2026
CHAIN Cohort: Prospective Multicenter Study of MASLD With Serial Liver Stiffness Assessments in Cardiovascular Care.
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Article in Liver international : official journal of the International Association for the Study of the Liver, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2citing papers in PubMed
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2 citing papers in PubMed.
- CHAIN Cohort: Prospective Multicenter Study of MASLD With Serial Liver Stiffness Assessments in Cardiovascular Care.Liver international : official journal of the International Association for the Study of the Liver · 2026Article
- A roadmap for heart-liver co-management in MASLD.Military Medical Research · 2026Article
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Authors and funding
90 authors.
Xiao-Dong ZhouMAFLD Research Center, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.ORCID 0000-0002-8534-0818
Ren Cheng-Han FanDepartment of Cardiovascular Medicine, the Heart Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.ORCID 0009-0000-2948-6962
Jian-Dong ChenDepartment of Cardiology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.ORCID 0000-0002-8103-9024
Xi-Qiao ZhouDepartment of Endocrinology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.ORCID 0000-0003-3122-3904
Qian TongDepartment of Cardiology, The First Hospital of Jilin University, Jilin, China.ORCID 0000-0002-5899-7910
Yan-Hang GaoDepartment of Hepatology, The First Hospital of Jilin University, Jilin, China.
Xiao-Qi WangDepartment of Cardiology, The Affiliated Central Hospital of Shandong First Medical University, Jinan, Shandong, China.
Ya-Kun JiangDepartment of Gastroenterology, The Affiliated Central Hospital of Shandong First Medical University, Jinan, Shandong, China.ORCID 0009-0001-6156-6695
Xiang-Yuan PuDepartment of Cardiology, the First Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China.
Yu ShiState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Zhejiang, China.ORCID 0000-0002-9392-7176
Ming-Wei WangDepartment of Cardiology, The Affiliated Hospital of Hangzhou Normal University, Zhejiang, China.ORCID 0000-0001-9060-5107
Jing LiuDepartment of Hepatology, The Affiliated Hospital of Hangzhou Normal University, Zhejiang, China.ORCID 0009-0004-1567-5569
Hai-Bing JiangDepartment of Cardiology, The Affiliated Traditional Chinese Medicine Hospital, Xinjiang Medical University, Xinjiang, China.
Li MaDepartment of Endocrinology, the Affiliated Traditional Chinese Medicine Hospital, Xinjiang Medical University, Xinjiang, China.ORCID 0000-0001-9284-2392
Xin-Gang ZhangDepartment of Cardiology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Yi-Ling LiDepartment of Gastroenterology, The First Hospital of China Medical University, Shenyang, Liaoning, China.ORCID 0000-0003-3209-8105
Su LinDepartment of Hepatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.ORCID 0000-0001-7517-9859
Hong-Ju YangDepartment of Geriatric Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Yao-Hong SongDepartment of Cardiology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Yan-Liang ZhangDepartment of Infectious Diseases, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Cheng-Zhi LuDepartment of Cardiology, Tianjin First Central Hospital, Tianjin, China.ORCID 0000-0002-4546-6395
Feng-Mei WangDepartment of Hepatology and Gastroenterology, Tianjin First Central Hospital, Tianjin, China.ORCID 0000-0001-9287-4183
De-Liang ShenDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.ORCID 0000-0002-1826-5141
Hong-Xia LiangDepartment of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Qiang LuoDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
En-Qiang ChenCenter of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID 0000-0003-3496-1283
Bo LiDepartment of Endocrinology, Weight Management and Metabolic Disease Center, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Bi-Hui ZhongDepartment of Gastroenterology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.ORCID 0000-0002-4638-7699
Ying-Wu LiuDepartment of Cardiology, The Third Central Hospital of Tianjin, Tianjin, China.ORCID 0000-0001-9939-4609
Qing YeDepartment of Gastroenterology and Hepatology, The Third Central Hospital of Tianjin, Tianjin, China.ORCID 0000-0001-5817-0713
Jie DengDepartment of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.ORCID 0000-0002-3691-1717
Fan-Pu JiDepartment of Hepatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.ORCID 0000-0002-1463-8035
Xian-Lun LiDepartment of Integrative Medicine Cardiology, China-Japan Friendship Hospital, Beijing, China.
Qian WangDepartment of Integrative Medicine Cardiology, China-Japan Friendship Hospital, Beijing, China.
Song YangDepartment of Infectious Diseases, China-Japan Friendship Hospital, Beijing, China.ORCID 0000-0001-6046-5756
Jingjing ZhaoDepartment of Cardiology, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Hui YangDepartment of Infectious Diseases, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Fang-Jie HouDepartment of Cardiology, Qingdao Municipal Hospital, Qingdao, Shandong, China.
Yong-Ning XinDepartment of Infectious Diseases, Qingdao Municipal Hospital, Qingdao, Shandong, China.ORCID 0000-0002-3692-7655
You-Fu HeDepartment of Cardiology, Guizhou Provincial People's Hospital, Guiyang, Guizhou, China.ORCID 0000-0003-4926-1706
Xin-Hua LuoDepartment of Infectious Diseases, Guizhou Provincial People's Hospital, Guiyang, Guizhou, China.
Yu-Feng GaoDepartment of Infectious Diseases, The Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.ORCID 0000-0003-1822-8161
Hao GuanDepartment of Cardiology, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Qi WangLiver Disease Center, Beijing Ditan Hospital, Capital Medical University, Beijing, China.ORCID 0009-0005-9129-1281
Zhong YeDepartment of Cardiology, The Third Affiliated Hospital of Sun Yat-Sen University Zhao-Qing Hospital, Guangzhou, Guangdong, China.
Yu-Bao ZhengDepartment of Infectious Diseases and Liver Diseases, The Third Affiliated Hospital of Sun Yat-Sen University Zhao-Qing Hospital, Guangzhou, Guangdong, China.ORCID 0000-0002-2630-2563
Bai-Zhen DeqingHepatology Department, Tibet Autonomous Region Tibetan Medical Hospital (Tibet Autonomous Region Tibetan Medicine Research Institute), Lhasa, Tibet, China.
Li-Ting ZhangDepartment of Hepatology, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
Zhen-Qi MaDepartment of Gastroenterology, Qinghai University Affiliated Hospital, Xining, Qinghai, China.
Cheng-Long ZhangDepartment of Cardiology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yan HuangDepartment of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xiao-Ping PengDepartment of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Xiao-Ping WuDepartment of Infectious Diseases, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.ORCID 0000-0003-2747-3185
Rui XiangDepartment of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Liang DengDepartment of Gastroenterology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID 0000-0003-3628-6808
Shali ShalaimaitiDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.ORCID 0000-0001-6842-3956
Ming-Feng XiaDepartment of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.ORCID 0000-0002-5650-0165
Yang ZhaoDuke-NUS Medical School, National University of Singapore, Singapore, Singapore.ORCID 0000-0002-6011-5948
Xiao-Fan MiaoDepartment of Cardiology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Xin-Yi SunDepartment of Endocrinology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Ge YuDepartment of Hepatology, The First Hospital of Jilin University, Jilin, China.
Yi-Long ManDepartment of Cardiology, The Affiliated Central Hospital of Shandong First Medical University, Jinan, Shandong, China.
Ruo-Qi ZhouState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Zhejiang, China.ORCID 0009-0003-0521-8711
Hao-Tian ZhangState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Zhejiang, China.
Jia-Ke TangDepartment of Cardiology, The Affiliated Hospital of Hangzhou Normal University, Zhejiang, China.ORCID 0000-0002-0987-9758
Cheng-Cheng FengDepartment of Endocrinology, the Affiliated Traditional Chinese Medicine Hospital, Xinjiang Medical University, Xinjiang, China.
Shuai-Ran ZhangDepartment of Gastroenterology, The First Hospital of China Medical University, Shenyang, Liaoning, China.ORCID 0009-0004-3962-8249
Yue-Yan HuDepartment of Geriatric Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Shu-Jun JiangDepartment of Infectious Diseases, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.ORCID 0000-0001-7995-4330
Jia LiDepartment of Hepatology and Gastroenterology, Tianjin First Central Hospital, Tianjin, China.ORCID 0009-0008-8002-7030
Guan-Yue SuDepartment of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Jun-Zhao YeDepartment of Gastroenterology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.ORCID 0000-0003-3163-4164
Bao-Xin QianDepartment of Gastroenterology and Hepatology, The Third Central Hospital of Tianjin, Tianjin, China.
Xiao LiangDepartment of Hepatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.ORCID 0000-0002-7623-3076
Yuan-Yuan RenDepartment of Infectious Diseases, China-Japan Friendship Hospital, Beijing, China.
Yan LiDepartment of Gastroenterology, The First Affiliated Hospital (Southwest Hospital) of Third Military Medical University (Army Medical University), Chongqing, China.
Xiao-Qian ZhangDepartment of Infectious Diseases, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Ning GengDepartment of Infectious Diseases, Qingdao Municipal Hospital, Qingdao, Shandong, China.
Hong PengDepartment of Infectious Diseases, Guizhou Provincial People's Hospital, Guiyang, Guizhou, China.ORCID 0000-0002-9426-7739
Kebinuer TuerxunInfectious Diseases and Hepatology Center, The First Affiliated Hospital of Xinjiang Medical University, Xinjiang, China.
Li-Gai LiuLiver Disease Center, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Chun-Yi HeDepartment of Infectious Diseases and Liver Diseases, The Third Affiliated Hospital of Sun Yat-Sen University Zhao-Qing Hospital, Guangzhou, Guangdong, China.
Jun-Feng LiDepartment of Hepatology, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.ORCID 0000-0002-5638-706X
Hong-Yan ZhangDepartment of Gastroenterology, Qinghai University Affiliated Hospital, Xining, Qinghai, China.
Li-Xia YangDepartment of Infectious Diseases, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.ORCID 0000-0002-0879-2263
Zheng-Jie LuDepartment of Gastroenterology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Jin ChaiDepartment of Gastroenterology, The First Affiliated Hospital (Southwest Hospital) of Third Military Medical University (Army Medical University), Chongqing, China.ORCID 0000-0002-8543-4566
Cheng-Lv HongDepartment of Cardiovascular Medicine, the Heart Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Ming-Hua ZhengMAFLD Research Center, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.ORCID 0000-0003-4984-2631
CHAIN Consortium
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD) is highly prevalent among patients with cardiovascular disease but remains underrecognized in routine cardiology practice. To address the limited prospective evidence on its progression and clinical impact, we established the CHAIN cohort, a prospective multicenter study enrolling approximately 15 000 adults undergoing coronary evaluation across 40 tertiary hospitals in China. Baseline assessment includes comprehensive cardiometabolic profiling and vibration-controlled transient elastography for evaluation of liver fibrosis and steatosis. Participants will undergo long-term follow-up with repeated liver assessments every 6-12 months. Primary outcomes include liver-related events and major adverse cardiovascular events, while secondary outcomes include longitudinal changes in liver fibrosis and steatosis and their associations with cardiometabolic risk factors and clinical outcomes. This cohort will provide longitudinal evidence to support risk stratification and integrated heart-liver management in cardiovascular care.
Indexed as
Cardiovascular DiseasesFatty LiverLiverLiver CirrhosisAdultChinaElasticity Imaging TechniquesFemaleHumansMaleMulticenter Studies as TopicObservational Studies as TopicProspective StudiesRisk Factorscardiometabolic diseasecardiovascular riskliver fibrosismetabolic dysfunction‐associated steatotic liver diseasevibration‐controlled transient elastography
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