Evidence map›Paper›PMID 42458961›Full record

ArticleGut microbes2026

Ecological restructuring of the nonbacterial fecal microbiome in obesity across human cohorts.

Laura Gallardo-Nuell, Marisel Rosell-Díaz, Josep Garre-Olmo, Josep Puig, Rafael Ramos, Javier Pons, Vicente Pérez-Brocal, Andrés Moya, Jordi Mayneris-Perxachs, José Manuel Fernández-Real

Abstract read
In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Laura Gallardo-NuellIntegrative Systems Medicine and Biology, Institut d'Investigació Biomèdica de Girona (IDIBGI-CERCA), Parc Hospitalari Martí i Julià, Edifici M2, Salt, Spain.ORCID 0009-0008-3004-1571
Marisel Rosell-DíazDepartment of Diabetes, Endocrinology and Nutrition, Dr. Josep Trueta University Hospital, Girona, Spain.
Josep Garre-OlmoDepartment of Nursing Science, School of Medicine, University of Girona, Girona, Spain.ORCID 0000-0002-7817-0814
Josep PuigDepartment of Medical Sciences, School of Medicine, University of Girona, Girona, Spain.ORCID 0000-0003-2791-6599
Rafael RamosDepartment of Medical Sciences, School of Medicine, University of Girona, Girona, Spain.ORCID 0000-0001-7970-5537
Javier PonsArea of Genomics and Health, Foundation for the Promotion of Sanitary and Biomedical Research of Valencia Region (FISABIO-Public Health), Valencia, Spain.ORCID 0000-0003-3298-5484
Vicente Pérez-BrocalArea of Genomics and Health, Foundation for the Promotion of Sanitary and Biomedical Research of Valencia Region (FISABIO-Public Health), Valencia, Spain.ORCID 0000-0002-1927-9676
Andrés MoyaArea of Genomics and Health, Foundation for the Promotion of Sanitary and Biomedical Research of Valencia Region (FISABIO-Public Health), Valencia, Spain.ORCID 0000-0002-2867-1119
Jordi Mayneris-PerxachsIntegrative Systems Medicine and Biology, Institut d'Investigació Biomèdica de Girona (IDIBGI-CERCA), Parc Hospitalari Martí i Julià, Edifici M2, Salt, Spain.ORCID 0000-0003-3788-3815
José Manuel Fernández-RealDepartment of Diabetes, Endocrinology and Nutrition, Dr. Josep Trueta University Hospital, Girona, Spain.ORCID 0000-0002-7442-9323

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity is a complex metabolic disorder increasingly linked to alterations in the gut microbiome. While most research has focused on bacterial communities, the contribution of nonbacterial components including viruses, archaea, and eukaryotic microorganisms remains insufficiently characterized. Here, we performed a multicohort analysis to investigate the role of the nonbacterial gut microbiome in obesity across three independent human cohorts. Using compositional analyses adjusted for key covariates and network based approaches, we identified consistent multikingdom alterations associated with obesity. Individuals without obesity showed a reproducible enrichment of methanogenic archaea, particularly

Indexed as

FecesGastrointestinal MicrobiomeObesityAgedArchaeaBacteriaCohort StudiesFemaleHumansMalearchaeabacteriopagesGut microbiomemetabolic diseaseobesity

Identifiers

PMID42458961
PMCPMC13378717

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.