ArticleCyborg and bionic systems (Washington, D.C.)2026
Heatwave Exposure Accelerates Biological Aging via Metabolic Dysregulation.
Article in Cyborg and bionic systems (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
12 authors.
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Abstract
Heatwave (HW) exposure is increasing rapidly under climate change, yet its potential role in accelerating biological aging and the underlying mechanisms remain poorly understood. Leveraging data derived from the China Health and Retirement Longitudinal Study (CHARLS), a large population-based cohort in China, we examined whether exposure to HWs is linked to more rapid biological aging in adults of middle and advanced age. The Klemera-Doubal method (KDM) was applied to derive estimates of biological age (BA), and biological age acceleration (BAA) was calculated as biological age minus chronological age. HW exposure during the 12 months preceding BA assessments in 2011 and 2015 was quantified using 12 definitions based on different temperature threshold and duration. Longitudinal associations between HW exposure and BAA were evaluated using a difference-in-differences design. Among 2,318 participants (mean age, 58.7 years; 46.9% men), greater HW exposure was significantly associated with higher BAA. Under the most stringent (HW12; ≥4 consecutive days above the 97.5th percentile), each additional HW event and day increased BAA by 0.531 years [95% confidence interval (CI), 0.341 to 0.722] and 0.057 years (95% CI, 0.037 to 0.076). Stronger associations were observed among participants with body mass index ≥ 23 kg/m
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