ArticleFrontiers in nutrition2026
Nutritional modulation of disease severity in acute pancreatitis: metabolic pathways, inflammatory signaling, and diet-responsive clinical outcomes.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The severity of acute pancreatitis (AP) is influenced by metabolic stress, systemic inflammation, gut barrier dysfunction, and nutritional status. While supportive care remains central to management, growing evidence indicates that nutritional modulation impacts disease severity, organ failure, and mortality. Methods: A retrospective study of 1,600 AP patients, diagnosed using the Revised Atlanta Criteria, was conducted to evaluate demographics, nutritional status, metabolic and inflammatory biomarkers, dietary patterns, gut barrier markers, and clinical outcomes. Early (≤48 h) versus delayed enteral nutrition (EN) was analyzed. Multivariable logistic regression adjusted for age, sex, BMI, etiology, and comorbidities was used to identify independent nutritional predictors of severe disease, persistent organ failure, and in-hospital mortality. Results: Age, BMI, and APACHE II score were major contributors to severity (APACHE II 16.8 ± 5.1 in severe vs. 6.8 ± 3.1 in mild AP; Conclusion: Nutritional modulation substantially affects metabolic, inflammatory, and clinical trajectories in AP, supporting early targeted nutrition as a core therapeutic strategy.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.