ReviewFrontiers in cell and developmental biology2026
Unraveling the role of lactylation in cell death and correlative diseases: a comprehensive review.
Review in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Lactylation is a newly identified post-translational modification and an important biological function of lactate. Numerous pathological disorders, including cancer and autoimmune and inflammatory diseases, are regulated by lactylation. Additionally, lactylation controls several physiological processes in cells, such as the production of proteins, cytokines, metabolism, and several forms of cell death. Cell death is responsible for tissue homeostasis, immune responses, tissue repair and tissue regeneration. Recent studies have revealed a close association between lactylation and cell death, underscoring their significance in the development and course of illness. The regulation of different types of cell death by lactylation involves the modulation of key cell death proteins. Therefore, clarifying the precise function of lactylation and related cell death mechanisms is essential for targeted disease therapies. Here, we provide an overview of how lactylation regulates cellular signaling in cells undergoing apoptosis, autophagy, pyroptosis, ferroptosis, and cuproptosis. Lactylation intervention to control cell death may offer new therapeutic insights for a number of human diseases.
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