Evidence map›Paper›PMID 42459873›Full record

ReviewFrontiers in genome editing2026

Ferrets and genetically modified ferrets as model organisms in biomedical research: a review.

Hongshu Sui, Yiyang Li, Yan Yang, Liangyu Jiang, Yaxin Jiao, Dongwei Liu, Haoyu Liu, Zekai Yang, Haorui Chen, Dongyu Zhang and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in genome editing, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hongshu Sui *Shandong Provincial Key Laboratory for Livestock Germplasm Innovation and Utilization, College of Animal Science and Technology, Shandong Agricultural University, Tai'an City, Shandong, China.
Yiyang Li *Department of Histology and Embryology, School of Clinical and Basic Medicine, Shandong First Medical University and Shandong Academy of Medical Science, Jinan, Shandong, China.
Yan Yang *Morphology Laboratory, School of Clinical and Basic Medical Sciences, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.
Liangyu Jiang *Department of Histology and Embryology, School of Clinical and Basic Medicine, Shandong First Medical University and Shandong Academy of Medical Science, Jinan, Shandong, China.
Yaxin JiaoDepartment of Histology and Embryology, School of Clinical and Basic Medicine, Shandong First Medical University and Shandong Academy of Medical Science, Jinan, Shandong, China.
Dongwei LiuDepartment of Histology and Embryology, School of Clinical and Basic Medicine, Shandong First Medical University and Shandong Academy of Medical Science, Jinan, Shandong, China.
Haoyu LiuDepartment of Histology and Embryology, School of Clinical and Basic Medicine, Shandong First Medical University and Shandong Academy of Medical Science, Jinan, Shandong, China.
Zekai YangDepartment of Histology and Embryology, School of Clinical and Basic Medicine, Shandong First Medical University and Shandong Academy of Medical Science, Jinan, Shandong, China.
Haorui ChenDepartment of Histology and Embryology, School of Clinical and Basic Medicine, Shandong First Medical University and Shandong Academy of Medical Science, Jinan, Shandong, China.
Dongyu ZhangDepartment of Histology and Embryology, School of Clinical and Basic Medicine, Shandong First Medical University and Shandong Academy of Medical Science, Jinan, Shandong, China.
Ruihan MaDepartment of Histology and Embryology, School of Clinical and Basic Medicine, Shandong First Medical University and Shandong Academy of Medical Science, Jinan, Shandong, China.
Yuxin JiangDepartment of Histology and Embryology, School of Clinical and Basic Medicine, Shandong First Medical University and Shandong Academy of Medical Science, Jinan, Shandong, China.
Mingjiu LuoShandong Provincial Key Laboratory for Livestock Germplasm Innovation and Utilization, College of Animal Science and Technology, Shandong Agricultural University, Tai'an City, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Domestic ferrets have served as experimental animals for over a century, offering a balance between practicality and biological relevance while bridging the gap between rodent and non-human primate models. Their anatomical and physiological similarities to humans, particularly in the respiratory and nervous systems, make ferrets an invaluable model for biomedical research across various disciplines. Recent advances in genome-editing technologies have enabled the efficient creation of genetically modified (GM) ferrets, significantly expanding their applications in basic and translational research. This review describes the unique biological characteristics of ferrets and their current applications in modeling human pathogenic infections, respiratory, gastrointestinal, and neurological disorders, as well as other complex diseases that rodent models fail to effectively recapitulate. We also discuss the challenges associated with ferret models and outline the future directions to enhance their utility, with the goal of advancing our understanding of human diseases and supporting the development of novel therapeutics.

Indexed as

animal modelbasic and translational researchferretgenetically modifiedrespiratory infection

Identifiers

PMID42459873
PMCPMC13368801

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.