ArticleFrontiers in microbiology2026
Transcutaneous auricular vagus nerve stimulation improves depressive-like behaviors in CUMS rats through regulation of gut microbiome, serum metabolites, and immune factors.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Depression is associated with microbiota-gut-brain (MGB) axis dysregulation. Transcutaneous auricular vagus nerve stimulation (taVNS) has shown antidepressant effects and modulated gut microbiota, but its potential to alleviate depression specifically via modulation of the MGB axis remains largely unexplored. Methods: Rats subjected to chronic unpredictable mild stress (CUMS) received taVNS for 3 weeks. We assessed depressive-like behaviors, gut microbiota, plasma metabolism, and inflammatory marker levels. Pearson correlation analyses examined relationships among these factors. Results: taVNS significantly improved depressive behaviors in CUMS rats. It shifted gut microbiota composition, enriching beneficial Conclusion: These findings indicate that taVNS may alleviate depression by enriching
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