Evidence map›Paper›PMID 42460041›Full record

ReviewFrontiers in bioengineering and biotechnology2026

Innovative microneedle-integrated hydrogels: a promising strategy for diabetic foot ulcer management.

Haiyang Yang, Haodong Hu, Yuhao Wang, Yiquan Ji, Jun Ma, Zhuoming Xu, Kang Ji, Jiayi Chen, Huanhuan Luo, Gang Chen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Haiyang YangJiaxing University Master Degree Cultivation Base, Zhejiang Chinese Medical University, Hangzhou, China.
Haodong HuJiaxing University Master Degree Cultivation Base, Zhejiang Chinese Medical University, Hangzhou, China.
Yuhao WangJiaxing University Master Degree Cultivation Base, Zhejiang Chinese Medical University, Hangzhou, China.
Yiquan JiJiaxing University Master Degree Cultivation Base, Zhejiang Chinese Medical University, Hangzhou, China.
Jun MaDepartment of Orthopedics, Jiaxing Key Laboratory of Basic Research and Clinical Translation on Orthopedic Biomaterials, The Second Affiliated Hospital of Jiaxing University, Jiaxing, China.
Zhuoming XuDepartment of Orthopedics, Jiaxing Key Laboratory of Basic Research and Clinical Translation on Orthopedic Biomaterials, The Second Affiliated Hospital of Jiaxing University, Jiaxing, China.
Kang JiDepartment of Orthopedics, Jiaxing Key Laboratory of Basic Research and Clinical Translation on Orthopedic Biomaterials, The Second Affiliated Hospital of Jiaxing University, Jiaxing, China.
Jiayi ChenDepartment of Orthopedics, Jiaxing Key Laboratory of Basic Research and Clinical Translation on Orthopedic Biomaterials, The Second Affiliated Hospital of Jiaxing University, Jiaxing, China.
Huanhuan LuoDepartment of Orthopedics, Jiaxing Key Laboratory of Basic Research and Clinical Translation on Orthopedic Biomaterials, The Second Affiliated Hospital of Jiaxing University, Jiaxing, China.
Gang ChenDepartment of Orthopedics, Jiaxing Key Laboratory of Basic Research and Clinical Translation on Orthopedic Biomaterials, The Second Affiliated Hospital of Jiaxing University, Jiaxing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic foot ulcer (DFU) is a common and severe complication in diabetic patients, characterized by prolonged wound healing, susceptibility to infection, and a high risk of amputation. Its complex pathophysiology involves persistent hyperglycemia, chronic inflammation, neuropathy, vascular impairment, infection, and cellular dysfunction. Conventional treatments often fall short in addressing these multifaceted challenges, Therefore, formulating safe and effective treatment strategies holds significant clinical significance. In recent years, Microneedle Hydrogels have emerged as a novel drug delivery system due to their minimally invasive application, high drug loading capacity and controlled release characteristics, This review highlights the unique advantages of Microneedle Hydrogel systems, including their structural characteristics, drug delivery capabilities, and mechanisms in promoting ulcer healing. At the same time, the challenges currently faced in research and the future development directions were explored, aiming to provide references for further research and clinical application in this field.

Indexed as

diabetic foot ulcersmicroneedle-based hydrogelmicroneedle (MN)targeted drug deliverywound repair and regeneration

Identifiers

PMID42460041
PMCPMC13369164

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.