Evidence map›Paper›PMID 42460055›Full record

ReviewInternational journal of biomaterials2026

Recent Advances in Mechanobiology-Mediated In Situ Tissue Engineering.

Henry Agbe, Bright N Jaato, Dominic A Dadzie, Benjamin Mensah Frimpong, Prudent M Mensah, Michael K Appiah, David Dodoo-Arhin, Alexandre Kabla

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Henry AgbeDepartment of Materials and Metallurgy Engineering, College of Engineering, Kwame Nkrumah University of Science and Technology, PMB University Post Office, KNUST, Kumasi, Ghana, knust.edu.gh.ORCID https://orcid.org/0000-0002-2080-6373
Bright N JaatoCenter for Nanointegration Duisburg-Essen (CENIDE), Carl-Benz Street 199, Duisburg, 47057, Germany.
Dominic A DadzieDepartment of Materials and Metallurgy Engineering, College of Engineering, Kwame Nkrumah University of Science and Technology, PMB University Post Office, KNUST, Kumasi, Ghana, knust.edu.gh.
Benjamin Mensah FrimpongDepartment of Materials and Metallurgy Engineering, College of Engineering, Kwame Nkrumah University of Science and Technology, PMB University Post Office, KNUST, Kumasi, Ghana, knust.edu.gh.
Prudent M MensahDepartment of Materials and Metallurgy Engineering, College of Engineering, Kwame Nkrumah University of Science and Technology, PMB University Post Office, KNUST, Kumasi, Ghana, knust.edu.gh.
Michael K AppiahDepartment of Materials and Metallurgy Engineering, College of Engineering, Kwame Nkrumah University of Science and Technology, PMB University Post Office, KNUST, Kumasi, Ghana, knust.edu.gh.
David Dodoo-ArhinDepartment of Materials Science & Engineering, University of Ghana, P.O. Box LG 77 Legon, Accra, Ghana, ug.edu.gh.
Alexandre KablaEngineering Department, University of Cambridge, Cambridge, CB2 1PZ, UK, cam.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tissue engineering aims to repair, replace, or regenerate damaged tissues by integrating principles of biology, engineering, and material science. Traditional ex vivo strategies, involving prefabricated cell/scaffold constructs followed by implantation, have shown promise but face significant limitations, including poor vascularization, immune rejection, high costs, and clinical translation challenges. These limitations have driven the emergence of in situ tissue engineering, which harnesses the body's intrinsic regenerative capacity by recruiting endogenous stem or progenitor cells to sites of injury for repair. A key requirement for successful in situ regeneration is the design of biomimetic three-dimensional scaffolds capable of delivering bioactive molecules such as growth factors and cytokines in a controlled and spatiotemporal manner. In addition to biochemical cues, mechanobiology plays a central role by regulating cell adhesion, migration, proliferation, and differentiation through mechanotransduction pathways involving cytoskeletal remodeling, extracellular matrix (ECM) dynamics, and nuclear signaling. This review highlights mechanobiology-mediated strategies, scaffold designs, and applications for hard and soft tissue repair, as well as challenges and future directions in regenerative medicine.

Indexed as

3D scaffoldsbiomimeticsin situ regenerationmechanobiologyscaffoldstissue engineering

Identifiers

PMID42460055
PMCPMC13370111

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.